{"id":"W2400990766","doi":"10.1016/j.celrep.2016.05.005","title":"CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"EIF4E; eIF4A; RNA Helicase A; PI3K/AKT/mTOR pathway; Initiation factor; EIF4G; Helicase; Biology; CRISPR; Translation (biology); Eukaryotic translation; Mechanistic target of rapamycin; Cell biology; RNA; Computational biology; Cancer research; Signal transduction; Genetics; Ribosome; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002450817,0.0003868024,0.000358733,0.000232752,0.0001693026,0.0003643123,0.0002891708,0.0004284173,0.001343413],"category_scores_gemma":[0.0002029583,0.0001490637,0.0002745282,0.0001253257,0.0002827082,0.0001431124,0.0002032412,0.00050573,0.0003934971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003665841,"about_ca_system_score_gemma":0.0002999647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007680042,"about_ca_topic_score_gemma":0.001320205,"domain_scores_codex":[0.9997975,0.00002748344,0.0000260768,0.00005381746,0.00006283959,0.00003227867],"domain_scores_gemma":[0.999871,0.00003824719,0.00004303078,0.00001938765,0.00001157295,0.00001673593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004254557,0.0000187974,0.00005528335,0.00001683947,0.000004729598,0.00004906173,0.000006626727,0.0002289745,0.9977565,0.0002284205,0.00005371656,0.001538479],"study_design_scores_gemma":[0.000008151827,0.00008980434,0.0003753361,0.000001929144,0.000007548734,0.0001159697,0.000005142975,0.001370555,0.9961542,0.00003772352,0.00182968,0.000003829735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623682,0.0009391326,0.02704765,0.0002601989,0.0001014285,0.0001548388,0.001686918,0.0008817044,0.00655982],"genre_scores_gemma":[0.9826596,0.0005957335,0.01174037,0.00007335366,0.00000626181,0.00006000304,0.0008159382,0.00009696063,0.003951801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001343413,"threshold_uncertainty_score":0.004494131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00733915612427843,"score_gpt":0.2450843461445714,"score_spread":0.2377451900202929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}