{"id":"W2401013275","doi":"10.2131/jts.41.403","title":"Ochratoxin A mediates MAPK activation, modulates <i>IL-2</i> and <i>TNF-α</i> mRNA expression and induces apoptosis by mitochondria-dependent and mitochondria-independent pathways in human H9 T cells","year":2016,"lang":"en","type":"article","venue":"The Journal of Toxicological Sciences","topic":"Mycotoxins in Agriculture and Food","field":"Agricultural and Biological Sciences","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"","keywords":"MAPK/ERK pathway; Survivin; Apoptosis; p38 mitogen-activated protein kinases; Kinase; Tumor necrosis factor alpha; Molecular biology; Cell biology; Biology; Mitochondrion; Autocrine signalling; XIAP; Programmed cell death; Chemistry; Caspase; Receptor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002267247,0.0005455615,0.0007643295,0.0001169534,0.001115831,0.0004084245,0.001182781,0.0005079262,0.0003263833],"category_scores_gemma":[0.0004305819,0.0001656381,0.0001530542,0.0006467743,0.001066452,0.0009369009,0.0005436165,0.0004440044,0.000006940655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009731968,"about_ca_system_score_gemma":0.00003994847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001280968,"about_ca_topic_score_gemma":0.0002896471,"domain_scores_codex":[0.9952474,0.000738033,0.001067407,0.0008001104,0.001314969,0.0008320654],"domain_scores_gemma":[0.9964969,0.001729712,0.0009172423,0.0001535441,0.0001881916,0.0005144805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009885646,0.0003231168,0.0006710092,0.000009052279,0.00002761688,0.000008341109,0.0003806486,0.000008955128,0.987869,0.0005868841,0.002403542,0.007612925],"study_design_scores_gemma":[0.001143464,0.002713897,0.05028998,0.0003409903,0.00006634513,0.0001092619,0.000478921,0.00002823345,0.9324629,0.006697178,0.005016681,0.0006521575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915103,0.002827918,0.00001820038,0.004161869,0.0003692906,0.0005961898,0.00006633433,0.00004233537,0.0004075835],"genre_scores_gemma":[0.9947324,0.00390142,0.0002745543,0.0003005583,0.0004765805,0.00003225961,0.000004862825,0.000004585859,0.0002728243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05540616,"threshold_uncertainty_score":0.8582184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820416090106801,"score_gpt":0.224315983969204,"score_spread":0.2061118230681361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}