{"id":"W2401013275","doi":"10.2131/jts.41.403","title":"Ochratoxin A mediates MAPK activation, modulates <i>IL-2</i> and <i>TNF-α</i> mRNA expression and induces apoptosis by mitochondria-dependent and mitochondria-independent pathways in human H9 T cells","year":2016,"lang":"en","type":"article","venue":"The Journal of Toxicological Sciences","topic":"Mycotoxins in Agriculture and Food","field":"Agricultural and Biological Sciences","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"","keywords":"MAPK/ERK pathway; Survivin; Apoptosis; p38 mitogen-activated protein kinases; Kinase; Tumor necrosis factor alpha; Molecular biology; Cell biology; Biology; Mitochondrion; Autocrine signalling; XIAP; Programmed cell death; Chemistry; Caspase; Receptor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009061046,0.0004602653,0.0001948445,0.0002034875,0.0001480759,0.0001682987,0.0000818144,0.0002089684,0.001734805],"category_scores_gemma":[0.00007285635,0.0001189687,0.0004103184,0.0001569291,0.0001596576,0.0002176552,0.0001434139,0.0004216713,0.0004692294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678241,"about_ca_system_score_gemma":0.0001364898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004486313,"about_ca_topic_score_gemma":0.0006460186,"domain_scores_codex":[0.99989,0.00001688054,0.00001070461,0.00002259551,0.00001800218,0.00004178397],"domain_scores_gemma":[0.9999343,0.000008229757,0.0000226591,0.000005926445,0.000009556314,0.00001938653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002875183,0.00002682301,0.0003207195,0.00004813957,0.000003921623,0.00007863963,0.00001191645,0.00001932217,0.9985613,0.00002108096,0.00002696767,0.0005936603],"study_design_scores_gemma":[0.00004819518,0.0008979992,0.01633411,0.00001308339,0.0000303196,0.0005345535,0.0000904077,0.0006248447,0.9794049,0.00007989271,0.001936085,0.000005467293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936312,0.002887166,0.001607473,0.0001004414,0.00005516462,0.00002861084,0.0004234544,0.00004889505,0.001217554],"genre_scores_gemma":[0.9957385,0.001146795,0.0007235044,0.00004913773,0.00001991674,0.00003295178,0.0004615434,0.000007315369,0.001820446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001734805,"threshold_uncertainty_score":0.005803466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820416090106801,"score_gpt":0.224315983969204,"score_spread":0.2061118230681361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}