{"id":"W2401143451","doi":"10.1126/science.aad3018","title":"The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":660,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Cancer Institute; Ludwig Institute for Cancer Research; American Brain Tumor Association","keywords":"Tumor microenvironment; Blockade; Cancer research; Glioblastoma; Cancer; Glioma; Receptor; Macrophage colony-stimulating factor; Medicine; Biology; Macrophage; Immunology; Tumor cells; Internal medicine; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008924614,0.0001646803,0.0002328069,0.000132026,0.00007956869,0.0002423985,0.000106094,0.0001813693,0.000438353],"category_scores_gemma":[0.00008302727,0.00008264196,0.0001244076,0.00007161871,0.0001884607,0.0001338267,0.0001408926,0.000443604,0.0001583249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002088942,"about_ca_system_score_gemma":0.0001392073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002625743,"about_ca_topic_score_gemma":0.000397036,"domain_scores_codex":[0.9999294,0.00001148939,0.000005199449,0.00001010846,0.00001433422,0.00002943986],"domain_scores_gemma":[0.9999434,0.000006349588,0.00002152615,0.000006217982,0.000005170673,0.00001734234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000292519,0.00005222477,0.001862856,0.00002100817,0.00000734848,0.0002077504,0.00002488172,0.0001051567,0.9939287,0.0001329395,0.00008155375,0.003283042],"study_design_scores_gemma":[0.0001019078,0.002315623,0.1057228,0.00001786591,0.00007107613,0.005116096,0.0001626099,0.003408544,0.8787303,0.0005564412,0.003778517,0.00001816266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986531,0.0006476222,0.0002975933,0.00004638072,0.000004102129,0.000006284861,0.00003536548,0.00002443083,0.0002850628],"genre_scores_gemma":[0.9993657,0.0002376726,0.0001238284,0.00001813645,0.000004785275,0.000005637185,0.00004376668,0.000003484172,0.000196889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000438353,"threshold_uncertainty_score":0.001515687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008201617976971,"score_gpt":0.2281877967537313,"score_spread":0.2199861787767603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}