{"id":"W2401298942","doi":"10.1111/evo.12958","title":"Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in<i>Pseudomonas aeruginosa</i>","year":2016,"lang":"en","type":"article","venue":"Evolution","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Clarendon Fund; Royal Society; Medical Research Council; European Commission; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Evolvability; Biology; Epistasis; Genotype; Pseudomonas aeruginosa; Genetics; Evolutionary biology; Mutation; Experimental evolution; Gene; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498655,0.0001236745,0.0001153091,0.00006817195,0.00009532554,0.0000129614,0.00008242311,0.00009639948,0.0000376025],"category_scores_gemma":[0.0001407164,0.0001085983,0.00004647294,0.0001179312,0.000150606,0.00001443453,0.00005216973,0.00007209678,0.00002247902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000934651,"about_ca_system_score_gemma":0.00009069535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008101606,"about_ca_topic_score_gemma":0.001036112,"domain_scores_codex":[0.9990273,0.00007367831,0.0002508353,0.0003274915,0.00009817065,0.000222558],"domain_scores_gemma":[0.9995386,0.00003912506,0.00006948614,0.0001973595,0.00007513266,0.00008027237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001522708,0.0001665804,0.6765652,0.00003606396,0.00004900945,0.00000201299,0.00014455,0.0004717408,0.3003232,0.002079519,0.0005596305,0.01945022],"study_design_scores_gemma":[0.0006341018,0.0001313654,0.9910309,0.00002132952,0.00002022951,0.000009363378,0.00005573735,0.001585481,0.001006248,0.003497104,0.001815316,0.0001928371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742693,0.0002645857,0.02413098,0.0005524043,0.0001485213,0.0001659788,0.00007823436,0.00001876793,0.0003711839],"genre_scores_gemma":[0.9979044,0.00005733504,0.001388817,0.0000362244,0.0001868576,0.00002138798,0.0001108432,0.00001171313,0.0002824644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3144657,"threshold_uncertainty_score":0.442851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112952107464646,"score_gpt":0.2665911832683285,"score_spread":0.255461662193682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}