{"id":"W2401592760","doi":"10.7554/elife.10607","title":"PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3","year":2016,"lang":"en","type":"article","venue":"eLife","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Max-Planck-Gesellschaft; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Bundesministerium für Gesundheit; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Genome Canada; Deutsche Krebshilfe; Pfizer","keywords":"Chromatin; Biology; Cell biology; ChIA-PET; ChIP-sequencing; PRC2; DNA; Transcriptional regulation; RNA; Chromatin immunoprecipitation; Chromatin remodeling; Genetics; Gene; Gene expression; Promoter; Histone H3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006625656,0.00008497458,0.00009272297,0.0000176936,0.0000203321,0.000005146229,0.00007781727,0.0000855941,0.00005037854],"category_scores_gemma":[0.00001388001,0.00006504127,0.00005526613,0.00001919974,0.0000850317,0.000001631488,0.00002417788,0.00001959282,0.00000627022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004806039,"about_ca_system_score_gemma":0.0000347651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004533727,"about_ca_topic_score_gemma":0.000002550797,"domain_scores_codex":[0.9994515,0.00001325402,0.0001375152,0.0001807589,0.00010396,0.000112992],"domain_scores_gemma":[0.9996575,0.000003913603,0.00004382953,0.0001878522,0.0000507881,0.00005618846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001944738,0.00001989081,0.00167481,0.000009806344,0.00003620651,5.336028e-7,0.0000452995,0.000001643284,0.9952429,0.0008919806,0.001081977,0.0009754987],"study_design_scores_gemma":[0.0007769964,0.0001337838,0.01407231,0.00001849311,0.00001573047,0.00001426823,0.00002807184,0.00005248871,0.9500518,0.0002395552,0.03443909,0.0001574004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956361,0.0006989967,0.002458954,0.0004360874,0.00003621405,0.00006284886,0.0001286361,0.000003972341,0.0005381824],"genre_scores_gemma":[0.9977363,0.0002014249,0.001017048,0.0003931357,0.00005157157,0.000004496815,0.000029116,0.00001372163,0.0005531995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04519109,"threshold_uncertainty_score":0.2652306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005665653197852076,"score_gpt":0.2232573837652399,"score_spread":0.2175917305673878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}