{"id":"W2401645747","doi":"10.1158/1557-3125.metca15-a20","title":"Abstract A20: Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates metabolic adaptation and enables glucose-independent tumor cell growth","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Phosphoenolpyruvate carboxykinase; Glutamine; Biology; Cell growth; Citric acid cycle; Glycolysis; Biochemistry; Gluconeogenesis; Metabolic pathway; Cancer cell; Warburg effect; Cancer; Metabolism; Amino acid; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353605,0.0004474336,0.0003446509,0.0004655678,0.0003448848,0.0008676771,0.0002381493,0.0004247548,0.006505998],"category_scores_gemma":[0.0001079551,0.0001682857,0.0002710579,0.0004980364,0.000324688,0.0004162415,0.0003203215,0.0005449565,0.001855784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007257644,"about_ca_system_score_gemma":0.0004054955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001095061,"about_ca_topic_score_gemma":0.001857166,"domain_scores_codex":[0.9998678,0.000008783421,0.000007051615,0.00005948453,0.00003548334,0.00002141292],"domain_scores_gemma":[0.9999198,0.000009074357,0.00001407377,0.000008681674,0.00001551863,0.00003290332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005224522,0.00005037226,0.001302197,0.0002478542,0.00002542135,0.0001902938,0.00002377183,0.000699217,0.9735231,0.0008643763,0.005325697,0.01722524],"study_design_scores_gemma":[0.00009034693,0.0003171268,0.05072884,0.00004917871,0.00007774351,0.00105379,0.00009527943,0.009497724,0.8638809,0.001482569,0.07269236,0.00003421493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8539777,0.03917947,0.03525111,0.006991675,0.002594966,0.0002217137,0.0158974,0.002852953,0.04303308],"genre_scores_gemma":[0.9420766,0.009744807,0.006781738,0.0004393474,0.0002868113,0.00005432887,0.008547775,0.0001926131,0.03187599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006505998,"threshold_uncertainty_score":0.0217647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02158083487398714,"score_gpt":0.2860287442108579,"score_spread":0.2644479093368708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}