{"id":"W2401751910","doi":"10.1038/ncomms11642","title":"Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Banting and Best Diabetes Centre, University of Toronto; Kidney Foundation of Canada","keywords":"Crosstalk; Mechanotransduction; Mechanosensitive channels; Myocardin; Cell biology; Cytoskeleton; Transcription factor; SMAD; Biology; Transforming growth factor; Actin; Myofibroblast; Actin cytoskeleton; Chemistry; Serum response factor; Cell; Gene; Genetics; Physics; Receptor; Ion channel; Fibrosis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009867894,0.0002114726,0.0001589753,0.0001034023,0.0001129839,0.0002554722,0.0001632507,0.0001168323,0.0009238705],"category_scores_gemma":[0.00008326871,0.0001606801,0.0001460698,0.00006319152,0.0001702708,0.0001817748,0.0003117218,0.0003000431,0.000223384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001867735,"about_ca_system_score_gemma":0.000136717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001848383,"about_ca_topic_score_gemma":0.0004610511,"domain_scores_codex":[0.9998914,0.00001669852,0.000005380632,0.00002641675,0.00002205945,0.00003810841],"domain_scores_gemma":[0.9999305,0.000009186912,0.0000247949,0.00000576401,0.000006558932,0.00002313979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004215719,0.000004490039,0.00009626273,0.000005309675,0.000001510184,0.00001598068,0.000003693603,0.00001855908,0.9995491,0.00005359662,0.000006193896,0.0002030487],"study_design_scores_gemma":[0.00001895354,0.0001072763,0.01053538,0.00000477162,0.00001310854,0.0001551792,0.00004220922,0.001918862,0.9860358,0.0000867459,0.001076543,0.000005122034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965963,0.0005633314,0.001924645,0.00004967719,0.00001181008,0.000006637536,0.0000604616,0.00003512278,0.0007521637],"genre_scores_gemma":[0.9981782,0.0002238372,0.0007228282,0.00002917296,0.000006225704,0.00001168042,0.00007966164,0.000008822388,0.0007395871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009238705,"threshold_uncertainty_score":0.00309068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063366425498913,"score_gpt":0.2566130782470418,"score_spread":0.2459794139920526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}