{"id":"W2401769767","doi":"10.1002/ijc.30197","title":"Risk of extracolonic cancers for people with biallelic and monoallelic mutations in <i>MUTYH</i>","year":2016,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Health and Medical Research Council; California Department of Public Health; Medical Research Council; Centers for Disease Control and Prevention; University of Southern California; National Cancer Institute; National Institutes of Health","keywords":"MUTYH; Medicine; Cancer; Endometrial cancer; Internal medicine; Oncology; Germline mutation; Population; Hazard ratio; Colorectal cancer; Mutation; Genetics; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000286652,0.0002175932,0.0002311963,0.0004937702,0.0001897789,0.0002935734,0.0001525056,0.0003098058,0.001899053],"category_scores_gemma":[0.0009000821,0.0002335033,0.0004837218,0.0004843682,0.0001229253,0.0001478748,0.0002869389,0.00040478,0.0002308619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001433502,"about_ca_system_score_gemma":0.0001931393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007323032,"about_ca_topic_score_gemma":0.008829364,"domain_scores_codex":[0.9998011,0.00004975459,0.00001629617,0.00004901602,0.0000333538,0.0000504281],"domain_scores_gemma":[0.9995236,0.00007055231,0.0002164196,0.0000416157,0.00003373033,0.0001141266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002256916,0.0000153787,0.9972233,0.000007884603,0.00004657654,0.0001292872,0.0000408438,0.00002951167,0.0002637306,0.00001955038,0.0001503092,0.00184801],"study_design_scores_gemma":[0.0000171896,0.0001112376,0.9981245,0.000006039965,0.00006901413,0.0009957645,0.00006576833,0.0001978181,0.0001290398,0.00003592607,0.0002438594,0.000003834165],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985775,0.0004712251,0.00006128954,0.00004658169,0.000006269313,0.000004478818,0.0003114235,0.00000750909,0.000513669],"genre_scores_gemma":[0.9987336,0.0002243662,0.00008609916,0.0000187508,0.00001310267,0.000004701134,0.0004034038,0.000002211022,0.0005138605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007323032,"threshold_uncertainty_score":0.01456082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147136597833419,"score_gpt":0.3136197361776246,"score_spread":0.3021483701992904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}