{"id":"W2401769767","doi":"10.1002/ijc.30197","title":"Risk of extracolonic cancers for people with biallelic and monoallelic mutations in <i>MUTYH</i>","year":2016,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Health and Medical Research Council; California Department of Public Health; Medical Research Council; Centers for Disease Control and Prevention; University of Southern California; National Cancer Institute; National Institutes of Health","keywords":"MUTYH; Medicine; Cancer; Endometrial cancer; Internal medicine; Oncology; Germline mutation; Population; Hazard ratio; Colorectal cancer; Mutation; Genetics; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633112,0.0000841114,0.0002382986,0.0001951845,0.00001297272,0.000006761027,0.0001157835,0.00004288059,0.000121636],"category_scores_gemma":[0.0001396909,0.00005237662,0.000066169,0.00009107502,0.00007803291,0.00008326627,0.00001512727,0.00009340918,3.716597e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004410603,"about_ca_system_score_gemma":0.0006634555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004673771,"about_ca_topic_score_gemma":0.005488459,"domain_scores_codex":[0.9990712,0.00001829337,0.0003560248,0.0001073942,0.0003367042,0.0001103134],"domain_scores_gemma":[0.9986067,0.0002220213,0.0003828107,0.00006362599,0.0006579062,0.00006691786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005539662,0.0001289723,0.8589339,0.00006919363,0.001115301,0.00002622293,0.00126422,0.002510732,0.04106056,0.0001252008,0.0009001167,0.0883259],"study_design_scores_gemma":[0.01467869,0.001853553,0.946447,0.001390602,0.0003918255,0.0002010667,0.0002381763,0.0003447607,0.0250479,0.001519996,0.007684114,0.000202291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918707,0.002038049,0.002004582,0.003230574,0.0004778276,0.0002154228,0.0000629725,0.000002955919,0.00009691285],"genre_scores_gemma":[0.9947467,0.00300929,0.00171023,0.000131926,0.0002246476,0.00004933625,9.010451e-7,0.00001393038,0.0001130686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0881236,"threshold_uncertainty_score":0.3062689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147136597833419,"score_gpt":0.3136197361776246,"score_spread":0.3021483701992904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}