{"id":"W2401819178","doi":"10.1371/journal.ppat.1005623","title":"A Neuronal Culture System to Detect Prion Synaptotoxicity","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Gene isoform; Prion protein; Neurotoxicity; Cell biology; Dendritic spine; Biology; Protease; Hippocampal formation; Neurodegeneration; Scrapie; Virology; Neuroscience; Chemistry; Biochemistry; Enzyme; Gene; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007234025,0.001004795,0.0008628687,0.0009504976,0.0007841207,0.0007920095,0.001441489,0.0007780537,0.002781814],"category_scores_gemma":[0.0005109386,0.0004010656,0.0005899781,0.000892869,0.0004495466,0.0005103477,0.0009176571,0.002240014,0.002963711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007523778,"about_ca_system_score_gemma":0.0009920431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004060234,"about_ca_topic_score_gemma":0.01070191,"domain_scores_codex":[0.9989065,0.000128189,0.0001971125,0.0002630157,0.0003908303,0.0001144597],"domain_scores_gemma":[0.9991333,0.000208424,0.0000768037,0.0002668411,0.0002386561,0.00007592571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007225403,0.00008378498,0.0003397083,0.0001246059,0.00002080694,0.0001619231,0.00007273883,0.00009121127,0.9955448,0.0004090399,0.0003496145,0.002729538],"study_design_scores_gemma":[0.00002728207,0.0004578849,0.002578448,0.00005436351,0.0001037813,0.0008701144,0.0000720644,0.00140383,0.9813321,0.0002716696,0.01280496,0.00002359063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6261966,0.02547784,0.2802861,0.001295423,0.002203307,0.002205327,0.01518696,0.002447646,0.04470066],"genre_scores_gemma":[0.6894229,0.02336465,0.2343611,0.0009094407,0.0002816741,0.003968643,0.02056712,0.0003850991,0.02673941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004060234,"threshold_uncertainty_score":0.009306073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009590573783656926,"score_gpt":0.2231392287856232,"score_spread":0.2135486550019663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}