{"id":"W2401862951","doi":"10.1007/s00401-016-1582-9","title":"Human-to-mouse prion-like propagation of mutant huntingtin protein","year":2016,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Korea Health Industry Development Institute; Canadian Institutes of Health Research; National Research Foundation","keywords":"Huntingtin; Biology; Induced pluripotent stem cell; Huntingtin Protein; Gliosis; Huntington's disease; Cell biology; Trinucleotide repeat expansion; Mutant; Neuroscience; Pathology; Genetics; Embryonic stem cell; Gene; Disease; Medicine; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004304207,0.0002422486,0.0001288722,0.0001140647,0.0001487796,0.0002184221,0.0001515298,0.0002417285,0.001113222],"category_scores_gemma":[0.000174161,0.00005382629,0.0001975503,0.00007196601,0.0001377762,0.0001481806,0.0001939924,0.0003633702,0.0004944562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009400066,"about_ca_system_score_gemma":0.0001465584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002210487,"about_ca_topic_score_gemma":0.0003302828,"domain_scores_codex":[0.9998254,0.00004466167,0.00002154707,0.00003407052,0.0000571638,0.00001714582],"domain_scores_gemma":[0.9998956,0.00002619061,0.00002124017,0.00002456062,0.00001399164,0.00001847005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007310702,0.00004408016,0.0002584405,0.00004345888,0.000009240637,0.0002015339,0.00002932177,0.00004633808,0.9967554,0.0003284194,0.0001013554,0.002109192],"study_design_scores_gemma":[0.00002359992,0.001076208,0.005773888,0.0000222118,0.00003599237,0.002667406,0.00004013986,0.001071271,0.9781092,0.0002311078,0.01094103,0.00000793866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747241,0.002629438,0.01813342,0.0001425518,0.00013835,0.000158048,0.000730452,0.0001854597,0.00315826],"genre_scores_gemma":[0.9859731,0.00152231,0.007705398,0.00008397903,0.00002126575,0.00005246345,0.001086386,0.00002091951,0.003534126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113222,"threshold_uncertainty_score":0.003724158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610592229496949,"score_gpt":0.2723278205654114,"score_spread":0.2362218982704419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}