{"id":"W2401946066","doi":"10.1101/gad.280941.116","title":"Evolution of a transcriptional regulator from a transmembrane nucleoporin","year":2016,"lang":"en","type":"article","venue":"Genes & Development","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; York University; JPB Foundation; G. Harold and Leila Y. Mathers Foundation; Leona M. and Harry B. Helmsley Charitable Trust; American Cancer Society; Howard Hughes Medical Institute","keywords":"Nucleoporin; Biology; Nuclear pore; Nucleoplasm; Cell biology; Nuclear transport; Transcription factor; Transcription (linguistics); Gene; Transcriptional regulation; Genetics; Transmembrane protein; Promoter; Regulation of gene expression; Nuclear protein; Cell nucleus; Gene expression; Cytoplasm; Nucleolus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005485603,0.00009376594,0.00008996936,0.00002870674,0.00003726165,0.000003181336,0.0000776911,0.00009023531,0.0001743851],"category_scores_gemma":[0.000004266023,0.00006875954,0.00005375971,0.00004014048,0.00003543927,0.000003543746,0.00001437923,0.00001717638,0.00001648192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002906692,"about_ca_system_score_gemma":0.0001057872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001381408,"about_ca_topic_score_gemma":0.00003685238,"domain_scores_codex":[0.9993418,0.00001654878,0.0001829549,0.0002140282,0.0001268868,0.0001177396],"domain_scores_gemma":[0.9997169,0.00000324498,0.00004428076,0.0001447224,0.00004914196,0.00004167135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001394967,0.00001895545,0.001588486,0.000006315695,0.00005109241,3.584715e-7,0.00006833207,0.000003105277,0.935845,0.0003589544,0.000235732,0.06168417],"study_design_scores_gemma":[0.0006167316,0.00005881414,0.1429418,0.00001829748,0.00001238355,0.000003858355,0.00002682373,0.000001948145,0.6431202,0.0003285361,0.2127457,0.0001248905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839521,0.0008826023,0.01444895,0.0001051975,0.0002541376,0.00008002388,0.00002295897,0.00001082166,0.0002431781],"genre_scores_gemma":[0.9931738,0.00009899348,0.006040014,0.00003758828,0.0001659608,0.000009066373,0.00004928584,0.00001289781,0.0004124133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2927248,"threshold_uncertainty_score":0.2803932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005787711952307907,"score_gpt":0.1882697291555004,"score_spread":0.1824820172031925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}