{"id":"W2401987785","doi":"10.1038/ni.3470","title":"CIS is a potent checkpoint in NK cell–mediated tumor immunity","year":2016,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":387,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Cancer research; Biology; Interleukin 12; Cytokine; Cell biology; Immunology; Cytotoxic T cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003721412,0.0005444158,0.0004645054,0.000409312,0.0003759909,0.001039108,0.0004428221,0.0004055616,0.004631536],"category_scores_gemma":[0.0002892138,0.000236849,0.0002621283,0.0002092255,0.0003827382,0.0007294456,0.0007470709,0.001619707,0.00185375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005483825,"about_ca_system_score_gemma":0.0004231707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001926258,"about_ca_topic_score_gemma":0.0003691977,"domain_scores_codex":[0.9996969,0.00003361023,0.0000226784,0.0000756549,0.00009513425,0.00007619403],"domain_scores_gemma":[0.9996936,0.00003780787,0.00006490294,0.00005541023,0.00005628882,0.00009201127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004109028,0.00003226605,0.0004871994,0.0001112467,0.00001069591,0.00009469629,0.00002373534,0.000197307,0.9904242,0.002027216,0.0003491719,0.005831297],"study_design_scores_gemma":[0.00002411966,0.0003958408,0.004412308,0.00001973969,0.00001661024,0.0003866432,0.00008870609,0.0006186247,0.9859548,0.0009628813,0.007111578,0.000008273179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9379077,0.01666026,0.01936661,0.0009277744,0.0008463326,0.0001401037,0.001296058,0.0009688938,0.02188623],"genre_scores_gemma":[0.9901307,0.001538366,0.001758933,0.0001159173,0.00006110135,0.0000275516,0.0006781669,0.00005998645,0.005629262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004631536,"threshold_uncertainty_score":0.01549405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005398807030968123,"score_gpt":0.2181035060668249,"score_spread":0.2127046990358568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}