{"id":"W2401987785","doi":"10.1038/ni.3470","title":"CIS is a potent checkpoint in NK cell–mediated tumor immunity","year":2016,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":387,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Cancer research; Biology; Interleukin 12; Cytokine; Cell biology; Immunology; Cytotoxic T cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003438283,0.0003281237,0.0004490383,0.0004455785,0.0001616519,0.00001284141,0.0004228485,0.001187863,0.00701351],"category_scores_gemma":[0.0003496668,0.0002337853,0.0001948617,0.0003263346,0.000278884,0.0002057099,0.000187155,0.00192708,0.005693125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694291,"about_ca_system_score_gemma":0.0001005938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002963785,"about_ca_topic_score_gemma":0.00004465611,"domain_scores_codex":[0.9977837,0.0004345251,0.0005956985,0.0004759223,0.00005253711,0.0006575967],"domain_scores_gemma":[0.9986072,0.0003112015,0.000253633,0.000636646,0.0001685302,0.00002285016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000983851,0.0003104132,0.0007610145,0.00001015925,0.0001276726,0.00001817733,0.0003059797,1.555329e-7,0.9765179,0.0002072998,0.01612554,0.00463191],"study_design_scores_gemma":[0.003723321,0.0003871862,0.01482983,0.00007052268,0.0000186409,0.000206955,0.0003306227,0.000001413354,0.6619507,0.000137273,0.3180461,0.0002974201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9500067,0.02085308,0.0001581221,0.005115452,0.01244023,0.0004832028,0.00004004383,0.0002708129,0.01063231],"genre_scores_gemma":[0.9797949,0.0007897764,0.00002342886,0.002060422,0.00003778992,0.00004799545,0.0001298316,0.00003364438,0.01708226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3145671,"threshold_uncertainty_score":0.9950811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005398807030968123,"score_gpt":0.2181035060668249,"score_spread":0.2127046990358568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}