{"id":"W2402010036","doi":"10.1016/j.jtho.2016.05.010","title":"ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers","year":2016,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Medicine; Methylation; Gene; DNA methylation; Lung cancer; Gene expression; Cancer research; Lung; Genetics; Pathology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005220039,0.0001101677,0.0002103049,0.0000846894,0.00003712224,0.00001769549,0.00009000949,0.0001733315,0.00002665662],"category_scores_gemma":[0.0002402418,0.00007633449,0.00003523356,0.00004140668,0.00006641505,0.00001710598,0.00007960494,0.00007455663,6.333151e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004463485,"about_ca_system_score_gemma":0.00009186012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005244328,"about_ca_topic_score_gemma":0.00003689491,"domain_scores_codex":[0.999017,0.0002151837,0.0003125762,0.000195939,0.00008601933,0.0001732837],"domain_scores_gemma":[0.9993298,0.00009485993,0.0002694169,0.0001272828,0.00007020737,0.0001084471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001187709,0.00002404095,0.1267398,0.00001215942,0.00002733379,0.00001207087,0.00009759455,0.00001397254,0.8404329,0.000001617703,0.00003429516,0.03248542],"study_design_scores_gemma":[0.0006071422,0.001044047,0.4762756,0.00009528726,0.00003708845,0.0003870912,0.00008764905,0.00003866484,0.5196517,0.0002226054,0.001431877,0.0001213107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961144,0.002860236,0.0003840304,0.0003203251,0.0001548935,0.00009027005,0.000002953399,0.000001939743,0.00007091256],"genre_scores_gemma":[0.994622,0.000853905,0.004053961,0.0001062528,0.0001730753,0.00000406936,0.000001255819,0.00001614579,0.0001693433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3495357,"threshold_uncertainty_score":0.311283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028899175980639,"score_gpt":0.3360287557402515,"score_spread":0.3257397639804451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}