{"id":"W2402010036","doi":"10.1016/j.jtho.2016.05.010","title":"ITPKA Gene Body Methylation Regulates Gene Expression and Serves as an Early Diagnostic Marker in Lung and Other Cancers","year":2016,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Medicine; Methylation; Gene; DNA methylation; Lung cancer; Gene expression; Cancer research; Lung; Genetics; Pathology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565069,0.0002165944,0.0002145853,0.0006981851,0.0002383453,0.0004509767,0.000192237,0.0002609591,0.001617869],"category_scores_gemma":[0.0003516897,0.0002027141,0.0001863325,0.0004115943,0.0002955821,0.000302043,0.0002807404,0.0004127389,0.0004073879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002956897,"about_ca_system_score_gemma":0.0002013166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008190681,"about_ca_topic_score_gemma":0.0009096785,"domain_scores_codex":[0.9998562,0.00002369584,0.00001188167,0.00004418239,0.0000348275,0.00002910896],"domain_scores_gemma":[0.9998109,0.00003957223,0.00007277886,0.0000194315,0.00002296209,0.00003426288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001105236,0.00004484721,0.156895,0.00009523725,0.00005052357,0.001459864,0.0001530444,0.0002479377,0.8202954,0.0006442398,0.0002967103,0.01871185],"study_design_scores_gemma":[0.00002652868,0.0002240392,0.6062477,0.0000222062,0.0001361723,0.006946527,0.0002775851,0.001800576,0.3784109,0.0008743583,0.005014517,0.00001880279],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911398,0.002329507,0.002779317,0.0001652092,0.00002791668,0.00001379264,0.0006164135,0.0001235953,0.002804427],"genre_scores_gemma":[0.9973199,0.0004989833,0.0009553655,0.00002027326,0.000009038574,0.000006748263,0.0002143791,0.00001488901,0.000960339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617869,"threshold_uncertainty_score":0.00541234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028899175980639,"score_gpt":0.3360287557402515,"score_spread":0.3257397639804451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}