{"id":"W2402074372","doi":"10.1158/1535-7163.mct-15-0849","title":"Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Hospital for Sick Children","keywords":"Medulloblastoma; Cancer research; Cell cycle; Radiation therapy; Cell cycle checkpoint; Cancer; Kinase; Radiosensitizer; Medicine; Chemistry; Biology; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006591678,0.000145285,0.0002055308,0.000037792,0.00004605897,0.000005811239,0.00006109218,0.00007581718,0.0001221279],"category_scores_gemma":[0.00001082857,0.00006967168,0.0001689067,0.0001571524,0.0001524078,0.0000206082,0.00003597407,0.00007324797,0.000007668523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307381,"about_ca_system_score_gemma":0.00008159089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001843358,"about_ca_topic_score_gemma":0.000006438214,"domain_scores_codex":[0.9990559,0.00008746509,0.0001842339,0.000190967,0.0002874109,0.0001940159],"domain_scores_gemma":[0.9994775,0.00002730607,0.00009523096,0.00024296,0.00009080268,0.00006618624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001595602,0.0002948246,0.001699448,0.000019008,0.0002927665,0.0001259454,0.00004524335,0.000003896318,0.9716586,0.0003836167,0.00008687013,0.02523026],"study_design_scores_gemma":[0.002789018,0.0002372462,0.005497212,0.0002562815,0.0003897533,0.00002326992,0.00001183237,0.00001682378,0.9871787,0.0002772191,0.003232143,0.00009053898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846562,0.001662675,0.0001620319,0.01247682,0.0001134914,0.000695955,0.00002355684,0.00003020283,0.0001790212],"genre_scores_gemma":[0.9972686,0.0001576878,0.000166905,0.002102904,0.00005514394,0.0001545357,0.000001692146,0.00002129869,0.00007119362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02513972,"threshold_uncertainty_score":0.2841129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02205573325539385,"score_gpt":0.2898538999910119,"score_spread":0.2677981667356181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}