{"id":"W2402088519","doi":"10.1158/1557-3125.advbc15-b16","title":"Abstract B16: Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Bromodomain; Triple-negative breast cancer; BRD4; Cancer research; BET inhibitor; Epigenomics; Biology; Chromatin; Cell growth; Cancer; Targeted therapy; Breast cancer; Transcription factor; Downregulation and upregulation; Enhancer; Cell cycle; Epigenetics; Gene; Gene expression; DNA methylation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438491,0.0001953201,0.0001912056,0.000286413,0.0001158315,0.00005277068,0.0002711473,0.0001716341,0.0001146198],"category_scores_gemma":[0.0005823601,0.0001574775,0.00005966077,0.0005073373,0.0002458592,0.0000158865,0.0002337133,0.000218312,0.00001715024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420434,"about_ca_system_score_gemma":0.0004094807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006952737,"about_ca_topic_score_gemma":0.002039468,"domain_scores_codex":[0.9974043,0.000512782,0.0002832703,0.0006905671,0.0005263494,0.000582667],"domain_scores_gemma":[0.9989206,0.00007973671,0.0000560486,0.0004275119,0.0002544571,0.0002616099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003032107,0.00003980813,0.001998118,0.00002205518,0.00002514078,0.00003721767,0.00008969359,0.000004232459,0.979521,0.0001008758,0.008341639,0.006788052],"study_design_scores_gemma":[0.001611968,0.0001290295,0.05187935,0.0003324775,0.000002909537,0.000004139893,0.00006705751,9.80059e-7,0.9261771,0.0004498712,0.01907103,0.0002741111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836192,0.002579216,0.0001579121,0.01222013,0.0001027902,0.0007181265,0.0002382614,0.00001217999,0.0003522349],"genre_scores_gemma":[0.9958904,0.0007836217,0.0002092783,0.0003473186,0.0001564622,0.0005593626,0.000006602771,0.00004295337,0.002004032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05334398,"threshold_uncertainty_score":0.6421747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02185799564652596,"score_gpt":0.3461006191008156,"score_spread":0.3242426234542896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}