{"id":"W2402105462","doi":"10.1097/jcp.0000000000000416","title":"Early Symptom Improvement as a Predictor of Response to Extended Release Quetiapine in Major Depressive Disorder","year":2015,"lang":"en","type":"review","venue":"Journal of Clinical Psychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of Environmental Health Sciences; AstraZeneca","keywords":"Quetiapine; Placebo; Quetiapine Fumarate; Clinical Global Impression; Major depressive disorder; Rating scale; Internal medicine; Hamilton Rating Scale for Depression; Psychology; Depression (economics); Antidepressant; Clinical trial; Major depressive episode; Post-hoc analysis; Psychiatry; Medicine; Atypical antipsychotic; Schizophrenia (object-oriented programming); Antipsychotic; Cognition; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002369073,0.0004248648,0.0009970138,0.0004619616,0.0001674419,0.0004933898,0.0003048198,0.0004820397,0.001135229],"category_scores_gemma":[0.004366072,0.0001516517,0.001330287,0.0002930145,0.0002083907,0.0003360643,0.0002694899,0.0007263363,0.000129936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001902269,"about_ca_system_score_gemma":0.0002283242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000753023,"about_ca_topic_score_gemma":0.001363397,"domain_scores_codex":[0.9990034,0.0005915512,0.0001129269,0.00009422737,0.0001206725,0.00007732098],"domain_scores_gemma":[0.99489,0.00369994,0.0006553861,0.0001699836,0.0001873648,0.0003973574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04958622,0.0007929999,0.914109,0.0001830317,0.002179502,0.0002753765,0.000116633,0.001094767,0.004124868,0.00002924419,0.000270304,0.02723805],"study_design_scores_gemma":[0.001082497,0.008091391,0.9861499,0.00001769937,0.0007424168,0.0002006059,0.0000474591,0.002695887,0.0006960111,0.00004100406,0.0002195567,0.00001552666],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9985709,0.0007384475,0.0002187316,0.00004698085,0.00001993024,0.00003299742,0.0001402796,0.00001082207,0.0002209299],"genre_scores_gemma":[0.9993657,0.00008588131,0.0001509931,0.00002838257,0.00002514582,0.00001868068,0.0001659786,0.00000200456,0.0001570811],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002369073,"threshold_uncertainty_score":0.01252902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06275894483301184,"score_gpt":0.4949017645329515,"score_spread":0.4321428196999396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}