{"id":"W2402129233","doi":"10.1371/journal.pbio.1002466","title":"Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling","year":2016,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Ministerio de Economía y Competitividad; Eusko Jaurlaritza; Ikerbasque, Basque Foundation for Science; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Evelyn F. McKnight Brain Research Foundation; Christopher and Dana Reeve Foundation; Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Euskal Herriko Unibertsitatea; McKnight Foundation; Epilepsy Foundation","keywords":"Microglia; Phagocytosis; Biology; Excitotoxicity; Inflammation; Cell biology; Glutamate receptor; Proinflammatory cytokine; Neuroinflammation; Immunology; Neuroscience; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000859009,0.0003578223,0.000380697,0.0002346838,0.0001500124,0.0002236267,0.0002177692,0.0003601429,0.0009957753],"category_scores_gemma":[0.0001051788,0.0001481845,0.0002391274,0.0001279551,0.0002897258,0.0002138038,0.0002083699,0.0005840963,0.000219208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455338,"about_ca_system_score_gemma":0.0002124188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081132,"about_ca_topic_score_gemma":0.001765901,"domain_scores_codex":[0.9998283,0.0000226446,0.00002529114,0.00003316105,0.0000333314,0.00005718289],"domain_scores_gemma":[0.9999114,0.000008776125,0.00003677609,0.00001061585,0.000008362451,0.00002405341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002662682,0.00004276573,0.0001008374,0.00003332629,0.00000656586,0.0000647893,0.00001562063,0.00003311162,0.9985278,0.00005163838,0.00002692991,0.0008302958],"study_design_scores_gemma":[0.00002689219,0.0008233144,0.004574359,0.000009582975,0.00003176762,0.0002787324,0.00006263,0.0004481662,0.9926841,0.00005872126,0.0009958945,0.000005986747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975051,0.0008861545,0.0007823173,0.00007190173,0.00002285349,0.00001789059,0.0001483679,0.00005039369,0.0005150532],"genre_scores_gemma":[0.9976036,0.0005881032,0.0005053186,0.00004071646,0.000006252671,0.00004321566,0.0001618206,0.000009439449,0.001041482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001081132,"threshold_uncertainty_score":0.003331244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03677786907000428,"score_gpt":0.2642117161880624,"score_spread":0.2274338471180581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}