{"id":"W2402250405","doi":"10.1016/j.biomaterials.2016.04.033","title":"Effect of methacrylic acid beads on the sonic hedgehog signaling pathway and macrophage polarization in a subcutaneous injection mouse model","year":2016,"lang":"en","type":"article","venue":"Biomaterials","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Research Foundation","keywords":"Materials science; Sonic hedgehog; Macrophage polarization; Hedgehog signaling pathway; Subcutaneous injection; Polarization (electrochemistry); Macrophage; Cell biology; Signal transduction; Biomedical engineering; Medicine; Biochemistry; Biology; Chemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003097606,0.0007680964,0.0004248348,0.0004066574,0.0002094068,0.0003489241,0.0002772033,0.0006305543,0.001296279],"category_scores_gemma":[0.0001272189,0.000302601,0.0005446889,0.0002244258,0.0004407375,0.0003755052,0.000218943,0.001015027,0.0003313766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001921189,"about_ca_system_score_gemma":0.0003645619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006152018,"about_ca_topic_score_gemma":0.0009600478,"domain_scores_codex":[0.9997318,0.00003280556,0.0000199925,0.00005790883,0.00005466638,0.0001026684],"domain_scores_gemma":[0.9997972,0.00003294127,0.0000587692,0.00002087263,0.00001865544,0.00007153299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001257504,0.0003521011,0.0001023238,0.00005476461,0.00001009338,0.00004460708,0.00001978532,0.00006445867,0.9965767,0.00005805722,0.00003644823,0.001423013],"study_design_scores_gemma":[0.00004610051,0.001393899,0.0009190699,0.000004721508,0.00003998454,0.00004033898,0.00001804196,0.0003067121,0.9967871,0.00002543044,0.0004130529,0.000005571313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948167,0.001216654,0.00246533,0.0001242591,0.0001281095,0.00006574834,0.0001849659,0.00008910031,0.0009091803],"genre_scores_gemma":[0.9882161,0.001423346,0.004515806,0.0001151025,0.00005588933,0.0001680622,0.000234825,0.00003572486,0.005235273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296279,"threshold_uncertainty_score":0.004336476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151429029284254,"score_gpt":0.246005815344062,"score_spread":0.2344915250512195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}