{"id":"W2402521871","doi":"10.1080/19382014.2016.1187352","title":"Ancestral genomic duplication of the insulin gene in tilapia: An analysis of possible implications for clinical islet xenotransplantation using donor islets from transgenic tilapia expressing a humanized insulin gene","year":2016,"lang":"en","type":"article","venue":"Islets","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary; Dalhousie University","funders":"","keywords":"Tilapia; Islet; Xenotransplantation; Biology; Transgene; Insulin; Gene; Transplantation; Gene duplication; Genetics; Internal medicine; Endocrinology; Fish <Actinopterygii>; Medicine; Fishery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003513836,0.0001630857,0.0003322545,0.0001137358,0.00009212871,0.00001340525,0.0002914996,0.0002199407,0.000009675673],"category_scores_gemma":[0.00003711674,0.0001215479,0.0002677108,0.0002867542,0.0001480465,0.00001651342,0.0000348655,0.0000659114,5.617547e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002724169,"about_ca_system_score_gemma":0.0001162362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001634802,"about_ca_topic_score_gemma":0.0001368776,"domain_scores_codex":[0.9982163,0.0001402457,0.0007535354,0.0005888375,0.0001029749,0.000198137],"domain_scores_gemma":[0.9986725,0.000038455,0.0004261491,0.0006405058,0.0001728783,0.00004949156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003526347,0.0001972821,0.01778568,0.00001263421,0.0001989957,1.083771e-7,0.0001473335,0.001019207,0.9756066,0.00001913103,0.000003706818,0.004656729],"study_design_scores_gemma":[0.001005646,0.0001560826,0.3753671,0.00002097846,0.0003557877,0.000001495418,0.00001456726,0.0008983241,0.6218497,0.0001348691,0.00006806184,0.0001273883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698628,0.00073754,0.02815776,0.000135515,0.0001140745,0.0004546303,0.0005240566,0.000006689125,0.000006933303],"genre_scores_gemma":[0.9927776,0.001090635,0.005478502,0.00004004898,0.0002289696,0.0000371386,0.0003025399,0.00002542028,0.00001907442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3575814,"threshold_uncertainty_score":0.4956581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06307346354696902,"score_gpt":0.3514649819988326,"score_spread":0.2883915184518636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}