{"id":"W2402521871","doi":"10.1080/19382014.2016.1187352","title":"Ancestral genomic duplication of the insulin gene in tilapia: An analysis of possible implications for clinical islet xenotransplantation using donor islets from transgenic tilapia expressing a humanized insulin gene","year":2016,"lang":"en","type":"article","venue":"Islets","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary; Dalhousie University","funders":"","keywords":"Tilapia; Islet; Xenotransplantation; Biology; Transgene; Insulin; Gene; Transplantation; Gene duplication; Genetics; Internal medicine; Endocrinology; Fish <Actinopterygii>; Medicine; Fishery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284558,0.0001165733,0.0001861276,0.0002504123,0.0001664928,0.0001956269,0.0001324426,0.000196274,0.001562544],"category_scores_gemma":[0.0001681346,0.0000967121,0.0002257473,0.0001589939,0.0003486736,0.0001628213,0.0002053036,0.0003049887,0.0002422504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843319,"about_ca_system_score_gemma":0.0002916218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003402337,"about_ca_topic_score_gemma":0.0004730746,"domain_scores_codex":[0.999943,0.000005686545,0.00000650946,0.00001674278,0.00001436222,0.00001374813],"domain_scores_gemma":[0.9998933,0.00003252698,0.00003153757,0.00001065729,0.000007345095,0.00002446295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005585275,0.00003021484,0.01215696,0.00005069341,0.00001235194,0.001532193,0.000127946,0.0002665084,0.9799605,0.0003794887,0.00002706024,0.004897594],"study_design_scores_gemma":[0.0001542234,0.001719153,0.3266189,0.00006406439,0.0003272272,0.01399685,0.001305819,0.004407397,0.6395331,0.001627424,0.01018396,0.00006190225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983215,0.0001333305,0.0009141052,0.00003153006,0.000004137338,0.000008272654,0.00009507407,0.000008611892,0.0004833924],"genre_scores_gemma":[0.998051,0.0002178368,0.00088127,0.00003331581,0.000003361682,0.00001094951,0.0002305771,0.000007785591,0.000563941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562544,"threshold_uncertainty_score":0.005227208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06307346354696902,"score_gpt":0.3514649819988326,"score_spread":0.2883915184518636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}