{"id":"W2402554684","doi":"10.1038/srep26419","title":"Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Heart, Lung, and Blood Institute; Faculty of Medical and Health Sciences, University of Auckland; Biotechnology and Biological Sciences Research Council; National Institute of General Medical Sciences; Medical Research Council; National Cancer Institute; National Institutes of Health; Manchester Collaborative Centre for Inflammation Research; University of Manchester; Wellcome Trust","keywords":"Glucocorticoid receptor; Biology; Interactome; Gene isoform; Nuclear receptor; Alternative splicing; Cell biology; Gene; Mitochondrial DNA; Subcellular localization; Function (biology); Transcriptome; Genetics; Computational biology; Gene expression; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096417,0.0001737422,0.0002048635,0.0001862085,0.0001242791,0.000328588,0.0001481852,0.0001425202,0.0009566834],"category_scores_gemma":[0.000129755,0.0001001203,0.0002120671,0.0001189961,0.000182862,0.0001815275,0.0002568058,0.0002538454,0.0002577959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002735192,"about_ca_system_score_gemma":0.000167534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006008529,"about_ca_topic_score_gemma":0.001666096,"domain_scores_codex":[0.999885,0.00001779674,0.000008866775,0.00003532452,0.0000255772,0.00002748346],"domain_scores_gemma":[0.9998825,0.00001635019,0.00002763083,0.0000160891,0.00002067017,0.00003676068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001858945,0.000007655788,0.0009771379,0.00003083982,0.00000878634,0.00008743857,0.00004279477,0.00002874174,0.9942989,0.0003596692,0.00008086097,0.003891315],"study_design_scores_gemma":[0.00009157199,0.0008202103,0.1984612,0.00005727315,0.0001083668,0.001788666,0.0007342164,0.001303067,0.7775604,0.001303057,0.01773059,0.00004131963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850588,0.006460567,0.003663427,0.0003272403,0.0000829474,0.00002168121,0.000582907,0.0000966756,0.003705851],"genre_scores_gemma":[0.9937208,0.001701439,0.000992951,0.00008090278,0.0000192888,0.00001147672,0.0003935901,0.00001721556,0.003062361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009566834,"threshold_uncertainty_score":0.003200412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006135777785839821,"score_gpt":0.223902191818305,"score_spread":0.2177664140324652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}