{"id":"W2402661058","doi":"10.1158/1078-0432.ccr-15-1790","title":"The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Cancer Institute; Wellcome Trust","keywords":"Multiple myeloma; Epigenetics; Medicine; Genetics; Biology; Cancer research; Oncology; Computational biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004490419,0.0001098354,0.0004065035,0.000156933,0.0001305968,0.0000221245,0.0001995702,0.0001453597,0.0003198652],"category_scores_gemma":[0.005409927,0.00004981627,0.0002460332,0.0003955307,0.001748184,0.00004788647,0.0001696264,0.0006349119,0.00007081727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212289,"about_ca_system_score_gemma":0.001100142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001286084,"about_ca_topic_score_gemma":0.001401814,"domain_scores_codex":[0.99651,0.0009201986,0.0008284044,0.000407848,0.0006820667,0.0006514607],"domain_scores_gemma":[0.9907172,0.007886841,0.00007549189,0.0005292025,0.0002760066,0.0005152614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001573637,0.0003133166,0.7574683,0.0000129155,0.0001648038,0.00005165074,0.00001797953,5.725137e-7,0.0001518107,0.00008552302,0.0004283691,0.2397311],"study_design_scores_gemma":[0.005014971,0.002028708,0.9897846,0.0001397232,0.0000181886,0.000005039054,0.00002805418,0.0002310623,0.0002404449,0.001902157,0.0005522694,0.00005477184],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901488,0.00143916,0.00002149097,0.006785415,0.00008072767,0.0007381708,0.0000366692,0.000008735832,0.0007407958],"genre_scores_gemma":[0.9868484,0.0112317,0.00005731482,0.00001988364,0.0002310039,0.00009958946,0.000002849165,0.00001831864,0.001490978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2396763,"threshold_uncertainty_score":0.6476579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2643911237102731,"score_gpt":0.5900468396188847,"score_spread":0.3256557159086116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}