{"id":"W2402915536","doi":"10.1093/annonc/mdv527.02","title":"315O_PR Antitumor activity and safety of pembrolizumab in patients with PD-L1-positive nasopharyngeal carcinoma: Interim results from a phase 1b study","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Medicine; Tolerability; Internal medicine; Response Evaluation Criteria in Solid Tumors; Oncology; Adverse effect; Phases of clinical research; Surgery; Gastroenterology; Clinical trial; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001195658,0.0008025706,0.001256225,0.0002641336,0.0003328561,0.0007779789,0.0005494913,0.0006102464,0.002584122],"category_scores_gemma":[0.0004649619,0.0003378224,0.001157416,0.000240976,0.0004942811,0.000854831,0.0002462167,0.002000628,0.0008631952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005653923,"about_ca_system_score_gemma":0.0006968716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006567013,"about_ca_topic_score_gemma":0.001415565,"domain_scores_codex":[0.9997116,0.0001014264,0.00001560485,0.00004150291,0.00004011421,0.00008969349],"domain_scores_gemma":[0.9997929,0.00004726615,0.00004319005,0.00002443563,0.00001805758,0.00007418882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3798834,0.02716226,0.02106393,0.001148789,0.002098239,0.0003113134,0.0002684342,0.003931728,0.1095127,0.0005060014,0.007098833,0.4470143],"study_design_scores_gemma":[0.2846844,0.5498785,0.1038077,0.0001269809,0.002866674,0.001170948,0.0001722984,0.0044826,0.03592096,0.0006034118,0.01618792,0.00009774516],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923407,0.003009154,0.0003437222,0.0003528491,0.00006535617,0.0004117405,0.0009301046,0.00009281105,0.002453723],"genre_scores_gemma":[0.9920132,0.001627328,0.0009557653,0.0005260209,0.00008314101,0.0003728061,0.002474927,0.00002423098,0.00192272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002584122,"threshold_uncertainty_score":0.00864476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06563245932026754,"score_gpt":0.3743396067828195,"score_spread":0.308707147462552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}