{"id":"W2403101744","doi":"10.1038/srep15045","title":"Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Mysore; University Grants Commission; Department of Biotechnology, Ministry of Science and Technology, India; Indian Institute of Science","keywords":"Phosphatidylserine; Reactive oxygen species; Cardiolipin; Platelet; Apoptosis; Chemistry; Platelet activation; Mitochondrion; Bilirubin; p38 mitogen-activated protein kinases; Oxidative stress; Endocrinology; Internal medicine; Biochemistry; Medicine; MAPK/ERK pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009839358,0.0003988374,0.0001544641,0.0001973568,0.0001221857,0.0001899609,0.0001186016,0.0001742098,0.001410368],"category_scores_gemma":[0.0001077226,0.00009270977,0.0001531109,0.0001376801,0.0001493696,0.000173691,0.0001890251,0.0003182649,0.000230771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399224,"about_ca_system_score_gemma":0.0001230142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001692653,"about_ca_topic_score_gemma":0.0002314943,"domain_scores_codex":[0.9999051,0.00002773441,0.000006889809,0.00001266226,0.00002604294,0.00002157854],"domain_scores_gemma":[0.9999621,0.0000058818,0.00001358266,0.000003360041,0.000006383757,0.000008583193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006342442,0.0001008842,0.0007479123,0.0002053839,0.00001992209,0.0004861809,0.00005659935,0.00007237559,0.9921256,0.0002126509,0.0001164814,0.005221827],"study_design_scores_gemma":[0.00006640635,0.001265415,0.01783379,0.00002176858,0.0000412046,0.001946678,0.00009481249,0.001303108,0.9728093,0.0003185234,0.004292022,0.000007035106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897517,0.006016377,0.001974557,0.0001721201,0.00003494652,0.00002325512,0.0001376853,0.00004101203,0.001848343],"genre_scores_gemma":[0.9953396,0.001974925,0.0007865587,0.00003850058,0.00001358421,0.0000268536,0.0001332083,0.000005394025,0.001681319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410368,"threshold_uncertainty_score":0.004718125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01416685859856449,"score_gpt":0.2505963194754252,"score_spread":0.2364294608768607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}