{"id":"W2403101744","doi":"10.1038/srep15045","title":"Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Mysore; University Grants Commission; Department of Biotechnology, Ministry of Science and Technology, India; Indian Institute of Science","keywords":"Phosphatidylserine; Reactive oxygen species; Cardiolipin; Platelet; Apoptosis; Chemistry; Platelet activation; Mitochondrion; Bilirubin; p38 mitogen-activated protein kinases; Oxidative stress; Endocrinology; Internal medicine; Biochemistry; Medicine; MAPK/ERK pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474806,0.0002371478,0.0002077965,0.0001167377,0.0001437878,0.0001348041,0.000137515,0.0001916137,0.00002387201],"category_scores_gemma":[0.000455704,0.0001976665,0.0001105287,0.0003010746,0.0001294857,0.00001321041,0.00007967367,0.00011233,0.00006299902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005992282,"about_ca_system_score_gemma":0.0002405089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000276537,"about_ca_topic_score_gemma":0.00001643252,"domain_scores_codex":[0.9976585,0.0001210738,0.000396499,0.0009532119,0.0004880957,0.0003826419],"domain_scores_gemma":[0.9983171,0.0000145794,0.0002235284,0.0009928051,0.000177082,0.0002749687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009588051,0.0000767804,0.0007998893,0.00001756014,0.00002514805,0.0001283316,0.00004876316,0.0001776446,0.9751081,0.000003703638,0.02058981,0.002928342],"study_design_scores_gemma":[0.0003446026,0.0004542734,0.0002432705,0.00003041145,0.00001277104,0.0001126527,0.00001682594,0.00008561128,0.9499286,0.0003474235,0.04818595,0.0002376402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932103,0.0000627888,0.0001755393,0.00007717253,0.002955815,0.0005354793,0.000001666274,0.00005414802,0.002927136],"genre_scores_gemma":[0.9950759,0.000001344607,0.00008900424,0.0001005936,0.000171917,0.00005443032,0.0003600492,0.00003099651,0.004115762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02759614,"threshold_uncertainty_score":0.8060607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01416685859856449,"score_gpt":0.2505963194754252,"score_spread":0.2364294608768607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}