{"id":"W2403313348","doi":"10.1385/1-59259-397-6:491","title":"Yeast as a Host to Screen for Modulators and Regulatory Regions of Mammalian Protein Kinase C Isoforms","year":2003,"lang":"en","type":"article","venue":"Humana Press eBooks","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"National Cancer Institute; Health Canada","keywords":"Protein kinase C; Saccharomyces cerevisiae; Schizosaccharomyces pombe; Yeast; Gene isoform; Biology; Mutagenesis; Biochemistry; Cell biology; Complementary DNA; Mutant; Kinase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785734,0.0001511265,0.0001524557,0.00006100392,0.0001136647,0.00002034105,0.0001035547,0.0001160401,0.000007560192],"category_scores_gemma":[0.00006680057,0.0001472813,0.00007951583,0.00001744744,0.00009465708,0.00000383672,0.00006012569,0.00004287898,9.215424e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008532983,"about_ca_system_score_gemma":0.00004571543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008638684,"about_ca_topic_score_gemma":0.00003950671,"domain_scores_codex":[0.9991012,0.00003990311,0.0002128274,0.0003140043,0.0001173134,0.0002147546],"domain_scores_gemma":[0.9993037,0.000003178915,0.00008221163,0.0003754845,0.00009021795,0.0001451985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001778657,0.00004001877,0.00001835871,0.0001300469,0.00005703275,0.000002943282,0.0001508351,0.00004857797,0.8692393,0.1255675,0.000340855,0.004226628],"study_design_scores_gemma":[0.0006680235,0.0002636969,0.0002450998,0.00006661966,0.00001992136,0.000006535965,0.00003787506,0.00004102586,0.9272788,0.000807436,0.07035529,0.0002096415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865388,0.00117087,0.005352675,0.00002405655,0.00003055943,0.001477069,0.00004984377,0.00001943939,0.005336741],"genre_scores_gemma":[0.9933631,0.000005474314,0.002232936,0.0001002869,0.00006125294,0.000188048,0.00002292115,0.00003012718,0.003995801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1247601,"threshold_uncertainty_score":0.6005955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02559140248058295,"score_gpt":0.2601669544603402,"score_spread":0.2345755519797572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}