{"id":"W2403324392","doi":"","title":"Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairment","year":2015,"lang":"en","type":"book-chapter","venue":"IUScholarWorks (Indiana University)","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Toronto General Hospital; University Health Network; University of Toronto","funders":"","keywords":"Dosing; Medicine; Renal function; Regimen; Discontinuation; Pharmacokinetics; Urology; Tranexamic acid; Anesthesia; Surgery; Internal medicine; Blood loss","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007493686,0.0006823149,0.001185165,0.0002861161,0.0003427438,0.0009873529,0.0008826972,0.001494618,0.001774571],"category_scores_gemma":[0.003330864,0.000398462,0.001299183,0.000360013,0.0003854309,0.0004067787,0.0006662269,0.001336684,0.0002072755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008533444,"about_ca_system_score_gemma":0.001556813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02631734,"about_ca_topic_score_gemma":0.009665719,"domain_scores_codex":[0.9997434,0.0001059107,0.00001483587,0.00004289611,0.00003953776,0.00005348484],"domain_scores_gemma":[0.9976569,0.001717892,0.0002324615,0.00005056447,0.0002358023,0.0001062486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001091906,0.00004463158,0.002161652,0.0000292722,0.00003390987,0.00008251591,0.00002815037,0.995673,0.0003290178,0.0004851441,0.0001894001,0.000833997],"study_design_scores_gemma":[0.0000284271,0.00004762215,0.0006338292,0.000005009707,0.0000150245,0.00002057281,0.00001761511,0.9986057,0.000134278,0.0002733924,0.0002120471,0.000006479754],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9420145,0.0008837662,0.04756655,0.0009879608,0.00007570966,0.0001865507,0.001468482,0.0001481999,0.006668298],"genre_scores_gemma":[0.9883679,0.000403333,0.007690119,0.0001390158,0.00002201436,0.0002419529,0.0007209751,0.00002476532,0.00238996],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02631734,"threshold_uncertainty_score":0.05232829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02404292620330832,"score_gpt":0.2270776090162422,"score_spread":0.2030346828129339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}