{"id":"W2403404860","doi":"10.1021/acs.biochem.5b00452","title":"Domain Selection in Metallothionein 1A: Affinity-Controlled Mechanisms of Zinc Binding and Cadmium Exchange","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Trace Elements in Health","field":"Nursing","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Chemistry; Cadmium; Metallothionein; Zinc; Metal; Binding site; Divalent; Stereochemistry; Biophysics; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002983701,0.0002280685,0.0002818475,0.0001555915,0.0002027537,0.0003191631,0.0003465943,0.000264969,0.000963686],"category_scores_gemma":[0.0004337204,0.0002192774,0.0001658975,0.0001094345,0.0002779949,0.0003265248,0.0002580217,0.0002947857,0.0004081085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003764866,"about_ca_system_score_gemma":0.0001559181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006493494,"about_ca_topic_score_gemma":0.0006963836,"domain_scores_codex":[0.9997767,0.00004840559,0.00001060307,0.00006924965,0.00005320783,0.00004189962],"domain_scores_gemma":[0.9997891,0.00008779576,0.00004283646,0.00001573179,0.0000279969,0.0000366342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001738211,0.00001276381,0.000900285,0.00002329939,0.000002672578,0.00003220609,0.00003018827,0.0002614455,0.9971005,0.0001706867,0.00001797839,0.001274209],"study_design_scores_gemma":[0.00002011921,0.0001089643,0.007057877,0.000003604024,0.000006004779,0.0003165328,0.0000407229,0.005664334,0.9858109,0.0001975179,0.0007619241,0.0000115657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944823,0.0005066731,0.004430731,0.00003009643,0.000003387667,0.00001244643,0.00003408577,0.00003043087,0.000469976],"genre_scores_gemma":[0.9976826,0.0001099339,0.001520731,0.00001687019,0.000002005467,0.000007170323,0.00004619336,0.000007063675,0.0006073599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000963686,"threshold_uncertainty_score":0.003223836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02515411236742901,"score_gpt":0.2898665097965773,"score_spread":0.2647123974291483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}