{"id":"W2403404860","doi":"10.1021/acs.biochem.5b00452","title":"Domain Selection in Metallothionein 1A: Affinity-Controlled Mechanisms of Zinc Binding and Cadmium Exchange","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Trace Elements in Health","field":"Nursing","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Chemistry; Cadmium; Metallothionein; Zinc; Metal; Binding site; Divalent; Stereochemistry; Biophysics; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001067177,0.0001603789,0.0003505147,0.0001182958,0.00005385847,0.0000179451,0.0001024294,0.0001871698,0.00002318943],"category_scores_gemma":[0.0002066703,0.0001645886,0.00004318029,0.0002502298,0.00004060829,0.00007662153,0.00004517753,0.0002037503,0.000004083935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717322,"about_ca_system_score_gemma":0.00007999693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001345486,"about_ca_topic_score_gemma":0.00008988546,"domain_scores_codex":[0.9986387,0.0001069636,0.0003957409,0.0002918733,0.000268593,0.0002980523],"domain_scores_gemma":[0.9993591,0.00008218759,0.0002135617,0.0001444001,0.00006094093,0.0001397963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000925733,0.0001551754,0.001844659,0.0002795212,0.00002824823,0.000004209321,0.0006060294,0.000004034409,0.9948389,0.0004043755,0.0003797742,0.0005293224],"study_design_scores_gemma":[0.006895582,0.000221454,0.0005370321,0.0001017635,0.00004079048,0.00002034333,0.0009206372,0.0001276613,0.988928,0.001632956,0.0003633511,0.0002104651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970245,0.0004808208,0.0003445212,0.0004922609,0.0003468113,0.0003631747,0.00001282193,0.00005573921,0.0008793924],"genre_scores_gemma":[0.9929067,0.000008617901,0.006626656,0.0000632099,0.0001108386,0.00004475691,0.0000117042,0.00002401033,0.0002034802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006282134,"threshold_uncertainty_score":0.6711728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02515411236742901,"score_gpt":0.2898665097965773,"score_spread":0.2647123974291483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}