{"id":"W2403613907","doi":"10.1091/mbc.e16-01-0062","title":"Specific functional pathologies of Cx43 mutations associated with oculodentodigital dysplasia","year":2016,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Fibroblast; Phenotype; Gene; Connexin; Genetics; Myofibroblast; Gap junction; Mutation; Cell biology; Cell culture; Cancer research; Intracellular; Molecular biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550486,0.0006909578,0.0003591293,0.0009498513,0.0003064306,0.0002752555,0.0001462682,0.0004032781,0.0007203206],"category_scores_gemma":[0.0002869824,0.0001815964,0.0002237432,0.0003238222,0.0005703024,0.0001374346,0.0005002233,0.0002516355,0.0001692024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002180894,"about_ca_system_score_gemma":0.0002105236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039772,"about_ca_topic_score_gemma":0.001579668,"domain_scores_codex":[0.9997475,0.00003216842,0.00004752018,0.00006171458,0.00007358679,0.00003761644],"domain_scores_gemma":[0.999801,0.00004698573,0.00007273948,0.0000172958,0.00002127384,0.00004086924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001785738,0.000026467,0.01425501,0.00004899614,0.0000200344,0.01008914,0.0001720603,0.0001010361,0.9730435,0.0001883779,0.00005158748,0.001825285],"study_design_scores_gemma":[0.00006175828,0.0004863865,0.3729485,0.00003178095,0.0001617019,0.09468606,0.0006852027,0.001497306,0.5264021,0.0005298018,0.002465407,0.00004391761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987651,0.0002378068,0.0002982703,0.00001407388,0.000003999355,0.000008668812,0.00009228797,0.0000128354,0.0005669508],"genre_scores_gemma":[0.9990568,0.0002469385,0.0003522918,0.00001687071,0.000002984475,0.000008281045,0.0001078916,0.00001060035,0.0001973632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039772,"threshold_uncertainty_score":0.002409697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008254379403945869,"score_gpt":0.2057868355179908,"score_spread":0.1975324561140449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}