{"id":"W2403652171","doi":"10.1073/pnas.1512783112","title":"ClpB N-terminal domain plays a regulatory role in protein disaggregation","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"CLPB; Cell biology; Protein aggregation; Protein folding; Chaperone (clinical); Heat shock protein; Plasma protein binding; Chemistry; Biophysics; Biology; AAA proteins; Biochemistry; Gene; Enzyme; ATPase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006476534,0.0002338929,0.000207451,0.00007861559,0.0001885782,0.0001609047,0.000165709,0.0002356545,0.0008015743],"category_scores_gemma":[0.0001228659,0.00008518421,0.0001535175,0.00007149329,0.0002030956,0.0001737437,0.0002163909,0.0002628561,0.000389174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821782,"about_ca_system_score_gemma":0.0002118219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007742506,"about_ca_topic_score_gemma":0.0008698456,"domain_scores_codex":[0.9999419,0.000007500543,0.000003608715,0.00002021558,0.00001418043,0.00001254219],"domain_scores_gemma":[0.9999276,0.00001419193,0.00001863991,0.000007678575,0.000009097217,0.00002283072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005502447,0.000007176669,0.000269898,0.00001494772,0.000001026751,0.0000985491,0.00001103195,0.00006361103,0.9986095,0.0000591402,0.00003155664,0.0007783859],"study_design_scores_gemma":[0.00001599582,0.00006657402,0.01987992,0.00001006834,0.000006852364,0.000718985,0.0000580778,0.003829925,0.9719268,0.0001396516,0.003337102,0.00001008802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941439,0.0007752114,0.003942295,0.00006630956,0.000008500146,0.00001008155,0.0001223249,0.00007514696,0.0008561873],"genre_scores_gemma":[0.9956074,0.0002820474,0.002260071,0.00005227164,0.000004234977,0.0000159304,0.0002962602,0.00001796872,0.001463701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008015743,"threshold_uncertainty_score":0.002681494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03524270319090095,"score_gpt":0.3220562296983623,"score_spread":0.2868135265074614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}