{"id":"W2403770148","doi":"10.1038/srep26502","title":"Membrane Topology and Structural Insights into the Peptide Pheromone Receptor ComD, A Quorum-Sensing Histidine Protein Kinase of Streptococcus mutans","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of King's College; Saint Mary's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Quorum sensing; Histidine kinase; Biology; Streptococcus mutans; Transmembrane protein; Transmembrane domain; G protein-coupled receptor; Signal transduction; Streptococcus suis; Cell biology; Membrane protein; Receptor; Biochemistry; Gene; Genetics; Bacteria; Virulence; Mutant; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007774571,0.0002888432,0.000148912,0.0001977387,0.0002259091,0.000277436,0.0002365484,0.0002753584,0.0006892544],"category_scores_gemma":[0.0001656142,0.0001307022,0.000164833,0.0001531267,0.0002162535,0.0003155951,0.0002083464,0.0004144376,0.0002157375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003193896,"about_ca_system_score_gemma":0.0002865417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009446641,"about_ca_topic_score_gemma":0.0007255061,"domain_scores_codex":[0.9999676,0.00000624422,0.000002827849,0.000004774952,0.00001294196,0.000005560009],"domain_scores_gemma":[0.9999552,0.000008356144,0.00001515037,0.000002705216,0.00000567972,0.00001292424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002180987,0.00005824682,0.001633054,0.0001388549,0.000008432773,0.0003658219,0.0000889107,0.001979604,0.9911957,0.001158595,0.0001257995,0.003028933],"study_design_scores_gemma":[0.0001431434,0.0007532864,0.07926997,0.0001001834,0.0001339409,0.003409964,0.001200072,0.07222221,0.8194721,0.005019884,0.01819756,0.00007775789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958091,0.0008783622,0.002007047,0.0002180284,0.00001412258,0.000008340788,0.0001605079,0.00003367748,0.0008707968],"genre_scores_gemma":[0.997117,0.0006804686,0.001539446,0.00003461117,0.000006521275,0.00000458794,0.0003386691,0.000005254805,0.0002734322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009446641,"threshold_uncertainty_score":0.002317369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00694081922855353,"score_gpt":0.2209352182069827,"score_spread":0.2139943989784291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}