{"id":"W2403816952","doi":"10.1385/1-59259-345-3:153","title":"Gene Therapy with Plasmids Encoding Cytokine- or Cytokine Receptor-IgG Chimeric Proteins","year":2003,"lang":"en","type":"article","venue":"Humana Press eBooks","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Cytokine; Genetic enhancement; Immunology; Receptor; Monoclonal antibody; Cytokine release syndrome; Biology; Cytokine receptor; Antibody; Medicine; Chimeric antigen receptor; Immunotherapy; Gene; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003841567,0.0006581217,0.0004425101,0.0004803439,0.0001430481,0.0005587467,0.0003936641,0.0006920426,0.003211443],"category_scores_gemma":[0.0003628043,0.0001994832,0.0003662026,0.0004020596,0.000512308,0.000428833,0.0003382239,0.001094092,0.001546787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005531866,"about_ca_system_score_gemma":0.0003882093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004677309,"about_ca_topic_score_gemma":0.0003493137,"domain_scores_codex":[0.9997198,0.00005963089,0.00001882912,0.00005956564,0.00008891436,0.00005327913],"domain_scores_gemma":[0.9998478,0.00006059289,0.00004004212,0.00001884177,0.00001243842,0.00002037293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001987098,0.000177803,0.0001450927,0.0002319761,0.00002498863,0.000115272,0.00005884351,0.0004492591,0.978411,0.003136101,0.0006573991,0.01639354],"study_design_scores_gemma":[0.0002583205,0.001586326,0.0008280036,0.00004606341,0.0001043688,0.0005774865,0.00002984337,0.002828328,0.9538139,0.0006560309,0.03925628,0.00001508194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6842104,0.02304307,0.2621314,0.002030112,0.001363188,0.0012612,0.002042933,0.002503857,0.02141389],"genre_scores_gemma":[0.8741117,0.01199819,0.07985467,0.0004061282,0.0001726346,0.0006145725,0.002409605,0.0002238577,0.03020858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003211443,"threshold_uncertainty_score":0.01074332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05383800469889626,"score_gpt":0.2974256490698207,"score_spread":0.2435876443709244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}