{"id":"W2403838837","doi":"10.1371/journal.pone.0154842","title":"Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Eli Lilly and Company; Audrey and Theodor Geisel School of Medicine at Dartmouth; National Institutes of Health; Universiteit van die Vrystaat; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Dartmouth College","keywords":"Placebo; Medicine; Human immunodeficiency virus (HIV); Antiretroviral drug; Randomized controlled trial; Deferiprone; Drug; Double blind; CCR5 receptor antagonist; Pharmacology; Virology; Antiretroviral therapy; Internal medicine; Viral load; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001789831,0.0009601035,0.001443376,0.0003210115,0.0002470248,0.0008465689,0.0005168373,0.001231114,0.003471312],"category_scores_gemma":[0.001285516,0.000319882,0.0008506301,0.0002508972,0.0006140966,0.0005248762,0.0003005126,0.001208789,0.0003469181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345987,"about_ca_system_score_gemma":0.0005856033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002657821,"about_ca_topic_score_gemma":0.000740185,"domain_scores_codex":[0.9995182,0.000256689,0.00003041974,0.00008401211,0.0000366604,0.00007401666],"domain_scores_gemma":[0.9995055,0.0001446777,0.0001193799,0.00004245318,0.00005326853,0.0001346943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.874011,0.0120312,0.001174443,0.001397619,0.0009716563,0.000152064,0.0001750131,0.001127813,0.05811851,0.0005075402,0.00139521,0.04893787],"study_design_scores_gemma":[0.629517,0.3498642,0.002946106,0.00008822978,0.001218803,0.0001901829,0.00005275957,0.001321107,0.01072294,0.0005754865,0.003459334,0.00004376918],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846696,0.006648101,0.001921257,0.0006565279,0.0003304672,0.003280143,0.0008985825,0.0001073558,0.001488006],"genre_scores_gemma":[0.9891557,0.002769023,0.002642886,0.0006473756,0.0001954119,0.002371571,0.0004554535,0.00002075646,0.001741911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003471312,"threshold_uncertainty_score":0.01161271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02573878181969669,"score_gpt":0.244215073876583,"score_spread":0.2184762920568863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}