{"id":"W2403838837","doi":"10.1371/journal.pone.0154842","title":"Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Eli Lilly and Company; Audrey and Theodor Geisel School of Medicine at Dartmouth; National Institutes of Health; Universiteit van die Vrystaat; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Dartmouth College","keywords":"Placebo; Medicine; Human immunodeficiency virus (HIV); Antiretroviral drug; Randomized controlled trial; Deferiprone; Drug; Double blind; CCR5 receptor antagonist; Pharmacology; Virology; Antiretroviral therapy; Internal medicine; Viral load; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003913451,0.0002526675,0.0009612492,0.0001537896,0.00003519358,0.00001385795,0.0001385946,0.0001237385,0.000007709117],"category_scores_gemma":[0.0002311607,0.0001491859,0.0001541242,0.0002689672,0.0003317931,0.00002176981,0.00005572739,0.00007746722,0.000003329273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002908267,"about_ca_system_score_gemma":0.0002194182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009543507,"about_ca_topic_score_gemma":0.0001597419,"domain_scores_codex":[0.9983262,0.0003103423,0.000567977,0.0003680795,0.0001680421,0.0002593164],"domain_scores_gemma":[0.9987475,0.0003601947,0.0003738076,0.0003705237,0.0001011171,0.00004683036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.4087057,0.001520503,0.001284873,0.0000198608,0.0001857485,3.912876e-7,0.0001130786,0.000004656193,0.5880574,0.00005548893,0.000006250501,0.00004607622],"study_design_scores_gemma":[0.4780706,0.0002452785,0.0002333059,0.00005473679,0.00015363,1.078549e-7,0.00003646445,0.0001237569,0.5209665,0.000009398965,0.000004582804,0.0001016589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937139,0.0003684679,0.0007156185,0.0001240681,0.00002524749,0.004491583,0.0004236015,0.00001013463,0.0001273814],"genre_scores_gemma":[0.9971147,0.0001981327,0.0003341378,0.00001424397,0.00007798954,0.001665379,0.0001594961,0.0000246248,0.0004113551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06936486,"threshold_uncertainty_score":0.6083625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02573878181969669,"score_gpt":0.244215073876583,"score_spread":0.2184762920568863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}