{"id":"W2403894042","doi":"10.2337/db15-1443","title":"4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass","year":2016,"lang":"en","type":"article","venue":"Diabetes","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Juvenile Diabetes Research Foundation United Kingdom","keywords":"mTORC1; Regulator; Cell biology; IRS2; Biology; Signal transducing adaptor protein; Cell growth; PI3K/AKT/mTOR pathway; Signal transduction; Insulin receptor; Insulin; Endocrinology; Insulin resistance; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193963,0.0005481406,0.0002118336,0.0003262684,0.0002067329,0.0003066816,0.0002394253,0.0002245949,0.001431842],"category_scores_gemma":[0.00007322732,0.0002533843,0.0001710448,0.0001543663,0.0002029306,0.0001980048,0.00027377,0.0004038954,0.0004292688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003478271,"about_ca_system_score_gemma":0.000169324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004777796,"about_ca_topic_score_gemma":0.0008611562,"domain_scores_codex":[0.9998944,0.00001074524,0.000005205081,0.00002996815,0.00003913156,0.00002059242],"domain_scores_gemma":[0.9999371,0.000004818179,0.00002751316,0.000005272934,0.000007592974,0.00001773433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001206303,0.00001274071,0.0005211578,0.00001762396,0.000006567791,0.00006750176,0.000005892402,0.00007408416,0.9968736,0.0001288911,0.00005319457,0.002118223],"study_design_scores_gemma":[0.00004374519,0.0001780425,0.02346677,0.000004970956,0.00002352822,0.0006373604,0.0000251008,0.001817975,0.9689695,0.0002895902,0.004535142,0.000008253851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986783,0.002615474,0.007869263,0.0001211453,0.00004705646,0.00002572577,0.0004201587,0.0003077428,0.001810335],"genre_scores_gemma":[0.9874808,0.001078978,0.004998106,0.00006921499,0.00002381981,0.0000373782,0.0009130487,0.00003738051,0.005361318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431842,"threshold_uncertainty_score":0.004790008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634549341553598,"score_gpt":0.229335312193797,"score_spread":0.212989818778261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}