{"id":"W2403905097","doi":"10.1096/fj.201600331r","title":"Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart","year":2016,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Manitoba; University Health Network","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"CIITA; Major histocompatibility complex; Gene knockdown; Mesenchymal stem cell; Biology; Immunology; Bone marrow; Cancer research; Immune system; Stem cell; MHC class II; Cell biology; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358656,0.000376251,0.0003165199,0.0001788942,0.0001247824,0.0003317862,0.0002262725,0.0002004904,0.001194383],"category_scores_gemma":[0.00006673262,0.0001374326,0.0002197073,0.00008288473,0.0002662925,0.0002065829,0.0001608267,0.0006303375,0.0003864419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001610638,"about_ca_system_score_gemma":0.0002152078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003362055,"about_ca_topic_score_gemma":0.0005524916,"domain_scores_codex":[0.9998825,0.00001237927,0.00001453828,0.00003163349,0.00003116713,0.00002783381],"domain_scores_gemma":[0.9999205,0.000006015167,0.00002594208,0.000008403883,0.000008294664,0.0000307236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004386668,0.00001824095,0.00006468315,0.00001893427,0.000002703273,0.00001038292,0.000005489512,0.000016906,0.9990141,0.00004342721,0.00002395729,0.0007373014],"study_design_scores_gemma":[0.00002955201,0.0003248362,0.002227525,0.00000529452,0.00002803355,0.00009821235,0.00003008772,0.0006502921,0.9946536,0.00003210332,0.00191739,0.000003147132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915399,0.002030755,0.004735456,0.0001304906,0.00006700218,0.00002601439,0.0001982621,0.0001530557,0.001119075],"genre_scores_gemma":[0.9930214,0.0011057,0.00124327,0.00006176349,0.0000158166,0.0000507264,0.0003669037,0.00003491009,0.004099357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194383,"threshold_uncertainty_score":0.003995597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04232464083764667,"score_gpt":0.2816575293156864,"score_spread":0.2393328884780398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}