{"id":"W2403954431","doi":"10.1007/978-1-62703-523-1_2","title":"Activating the NLRP3 Inflammasome Using the Amyloidogenic Peptide IAPP","year":2013,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Medical Research Council; National Health and Medical Research Council; Canadian Institutes of Health Research; Canadian Diabetes Association","keywords":"Inflammasome; Amylin; Amyloid (mycology); Chemistry; Innate immune system; Cell biology; Proinflammatory cytokine; Peptide; Extracellular; Islet; Biochemistry; Inflammation; Receptor; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004701611,0.0003675209,0.0002502493,0.0002889875,0.0002679331,0.0005483284,0.0001599967,0.0004069353,0.0007216267],"category_scores_gemma":[0.0002798826,0.0001651857,0.0004603011,0.0002307996,0.0003529923,0.0005370631,0.0004517688,0.0009039462,0.0003904006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000210905,"about_ca_system_score_gemma":0.000292135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001746592,"about_ca_topic_score_gemma":0.0002839066,"domain_scores_codex":[0.9996293,0.0001061401,0.00005146116,0.00007049909,0.00009890927,0.00004374442],"domain_scores_gemma":[0.9998272,0.00005041614,0.0000464718,0.00003378066,0.00001832446,0.00002375409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004324214,0.00002230328,0.0001026124,0.00007576381,0.000005803035,0.0001065822,0.00002673422,0.00008352344,0.9971312,0.0003363001,0.00006534706,0.002000436],"study_design_scores_gemma":[0.00001547169,0.000277515,0.00061345,0.00001942866,0.00001364389,0.0006529528,0.00004383795,0.000503615,0.990427,0.0003950687,0.007029242,0.000008574163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7706444,0.0162915,0.1990994,0.001635542,0.0005432799,0.0007198947,0.0006400528,0.0006187501,0.009807206],"genre_scores_gemma":[0.868905,0.01500385,0.1101843,0.0007508831,0.0001020491,0.0003233244,0.0005133919,0.00007336057,0.004143995],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0007216267,"threshold_uncertainty_score":0.002486467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02710311627578445,"score_gpt":0.3766404538741691,"score_spread":0.3495373375983847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}