{"id":"W2403998898","doi":"10.1001/jamaoncol.2016.0494","title":"Genomic Alterations in Cell-Free DNA and Enzalutamide Resistance in Castration-Resistant Prostate Cancer","year":2016,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":384,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute","keywords":"Enzalutamide; Prostate cancer; Medicine; Interquartile range; Oncology; Internal medicine; Cell-free fetal DNA; Prostate-specific antigen; Cancer; Androgen deprivation therapy; Androgen receptor; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163473,0.0001594185,0.0001789926,0.0007331651,0.0001485457,0.0003315747,0.0001807006,0.0001872621,0.00133541],"category_scores_gemma":[0.0005689616,0.0001271181,0.00007679101,0.0005800983,0.0002215441,0.0001164303,0.0001632371,0.0001636695,0.00009703413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005612668,"about_ca_system_score_gemma":0.0004857141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009839244,"about_ca_topic_score_gemma":0.02363254,"domain_scores_codex":[0.9998606,0.00002834619,0.000009179063,0.00003879597,0.00004517184,0.0000178477],"domain_scores_gemma":[0.9997333,0.00005435102,0.0001228763,0.00001304005,0.00003770207,0.00003882959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001360517,0.000101085,0.9322835,0.0001279974,0.0001147099,0.0006791707,0.0002320771,0.0006148868,0.03901049,0.00005863184,0.0002577954,0.02515908],"study_design_scores_gemma":[0.00001279068,0.0002035912,0.9960433,0.000007045858,0.00002414094,0.0008190669,0.00008796439,0.0002423601,0.002142891,0.00003003901,0.0003825535,0.000004272237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981387,0.0007712457,0.000252586,0.00003513399,0.000001937763,0.00001343703,0.0004089972,0.00001484561,0.0003631405],"genre_scores_gemma":[0.9991486,0.0001622972,0.0001841659,0.00002612771,0.000002077841,0.000006860399,0.000253175,0.000001960832,0.000214721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009839244,"threshold_uncertainty_score":0.01956391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02452938334777873,"score_gpt":0.3308476599576475,"score_spread":0.3063182766098688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}