{"id":"W2403998898","doi":"10.1001/jamaoncol.2016.0494","title":"Genomic Alterations in Cell-Free DNA and Enzalutamide Resistance in Castration-Resistant Prostate Cancer","year":2016,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":384,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute","keywords":"Enzalutamide; Prostate cancer; Medicine; Interquartile range; Oncology; Internal medicine; Cell-free fetal DNA; Prostate-specific antigen; Cancer; Androgen deprivation therapy; Androgen receptor; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002550051,0.0001159133,0.0002565492,0.0001964137,0.0000496671,0.00001799919,0.00007663265,0.000115742,0.0001020287],"category_scores_gemma":[0.00008840636,0.00007822253,0.00002318606,0.0001791594,0.0001426795,0.0001196049,0.0000520131,0.0001647524,0.00001194038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001030824,"about_ca_system_score_gemma":0.0007970233,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005483668,"about_ca_topic_score_gemma":0.03588338,"domain_scores_codex":[0.9988305,0.0001040243,0.0002962807,0.0003035322,0.0001251486,0.0003405103],"domain_scores_gemma":[0.999348,0.0001916226,0.00006382632,0.0002274858,0.00006505114,0.0001039963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006173318,0.0004461355,0.1773841,0.0001971934,0.0000406572,0.00117485,0.00353038,0.000006285965,0.7819175,0.001194623,0.005799318,0.0221357],"study_design_scores_gemma":[0.02583379,0.0008780787,0.8890166,0.0004739781,0.00003775886,0.00002257033,0.000420293,0.00002667756,0.02840983,0.003397026,0.05124104,0.000242415],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604585,0.003353446,0.000003455905,0.02886661,0.00008820726,0.0006701549,0.00007924946,0.00001449716,0.006465864],"genre_scores_gemma":[0.986956,0.002559217,0.0004726403,0.0003500611,0.0001065338,0.0003622188,0.0000129591,0.00001591288,0.009164471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7535076,"threshold_uncertainty_score":0.9817092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02452938334777873,"score_gpt":0.3308476599576475,"score_spread":0.3063182766098688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}