{"id":"W2404004983","doi":"","title":"Synthesis and antitumor cytotoxicity evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine imidazole containing polyamide conjugates.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cytotoxicity; Imidazole; Chemistry; Conjugate; Cancer cell; Cytotoxic T cell; Polyamide; Structure–activity relationship; Stereochemistry; In vitro; Pyrrole; Biological activity; Cancer; Combinatorial chemistry; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001931622,0.0002602738,0.0005058619,0.0001221453,0.0001288315,0.0000307242,0.0001729518,0.000148038,0.0009660849],"category_scores_gemma":[0.003345483,0.0002603684,0.00009995294,0.000153011,0.0002778098,0.0001880377,0.00004993789,0.0001714238,0.000002968209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007559086,"about_ca_system_score_gemma":0.0000835242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004195907,"about_ca_topic_score_gemma":0.000008266939,"domain_scores_codex":[0.9980334,0.0001449069,0.0004971817,0.0004230232,0.0004186715,0.0004828121],"domain_scores_gemma":[0.99817,0.0008135472,0.0003482546,0.000274573,0.0002178303,0.0001757856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002325125,0.000667247,0.03783136,0.0002729322,0.000528467,0.000006458975,0.0004138195,0.000205276,0.9098205,0.001406269,0.0001990125,0.04841616],"study_design_scores_gemma":[0.001381852,0.00001025835,0.1101447,0.00003930237,0.0002380271,0.00001796148,0.0002549552,0.001205111,0.8859673,0.0001033605,0.0003778392,0.000259291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806766,0.001043413,0.00004776664,0.0001978951,0.00008974969,0.0004069692,0.00009877318,0.00006134465,0.01737751],"genre_scores_gemma":[0.9981148,0.00008654936,0.0003000538,0.0001307572,0.00006968951,0.001208329,0.000008263009,0.00003162331,0.00004992938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07231336,"threshold_uncertainty_score":0.9999849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06048955236647287,"score_gpt":0.277880901145361,"score_spread":0.2173913487788882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}