{"id":"W2404247122","doi":"10.1074/jbc.m116.731190","title":"Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated Proteolysis","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; University of Ottawa; Purdue University","keywords":"Degron; Ubiquitin ligase; Proteolysis; CDC20; Anaphase-promoting complex; F-box protein; Cell biology; Biology; Ubiquitin-Protein Ligases; Cell division control protein 4; Mitosis; Ubiquitin; Biochemistry; Chemistry; Molecular biology; Cell cycle; Cell; Anaphase; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":{"nature":"Correction","reason":"Duplication of/in Image;Error in Data;Error in Image;Error in Text;","date":"3/24/2017 0:00","openalex_flagged":false},"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867371,0.0003193375,0.0003649373,0.0002379497,0.0001513909,0.0004592573,0.000172599,0.0002259517,0.0007168446],"category_scores_gemma":[0.0002060817,0.0002149363,0.0001702932,0.0001734641,0.0002772289,0.0002166775,0.0001957841,0.0003157438,0.0003092578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005917901,"about_ca_system_score_gemma":0.0003380669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195648,"about_ca_topic_score_gemma":0.001257817,"domain_scores_codex":[0.9997261,0.00002965902,0.00003235384,0.00008390891,0.00007952804,0.00004851299],"domain_scores_gemma":[0.9997796,0.00003805963,0.00007819143,0.00002815635,0.00002807851,0.00004782824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008279475,0.00001027842,0.0006119789,0.00001940514,0.000003020608,0.00005034198,0.000003885865,0.00003842163,0.9987336,0.00003926666,0.000009634848,0.0003974777],"study_design_scores_gemma":[0.000008943893,0.00009735712,0.02253695,0.000002246196,0.000008814001,0.0004383944,0.00001419876,0.0007123013,0.9755436,0.00003027776,0.0006026211,0.000004201728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961803,0.001588878,0.001447638,0.00003736424,0.000007967605,0.00001240511,0.0002222351,0.00005904317,0.0004441467],"genre_scores_gemma":[0.9973443,0.000374818,0.001338985,0.00001908256,0.000003600652,0.00001027539,0.0003702916,0.00001097053,0.0005276524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195648,"threshold_uncertainty_score":0.00429374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0348544417448562,"score_gpt":0.2563876222075809,"score_spread":0.2215331804627247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}