{"id":"W2404595262","doi":"10.1038/ncomms11704","title":"Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Directorate for Biological Sciences; National Institutes of Health; University of Aberdeen; Massachusetts Institute of Technology; Biotechnology and Biological Sciences Research Council; Fundo para o Desenvolvimento das Ciências e da Tecnologia; Universidade de Macau; Wellcome Trust; Burroughs Wellcome Fund","keywords":"HSF1; Candida albicans; Biology; Nucleosome; Heat shock protein; Promoter; Heat shock; Cell biology; Chromatin; Hsp90; Tiling array; Heat shock factor; Transcription factor; Chaperone (clinical); Virulence; Gene expression; Transcription (linguistics); Gene; Genetics; Transcriptome; Hsp70","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002745662,0.0001367331,0.0001202556,0.00005188331,0.0001665865,0.00003712582,0.0004155434,0.0003814333,0.000008768633],"category_scores_gemma":[0.0001319309,0.0001037285,0.00002924742,0.0001319136,0.0002440826,0.000008058533,0.0002152262,0.0005091316,0.000001467277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005055348,"about_ca_system_score_gemma":0.0001649503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001161826,"about_ca_topic_score_gemma":0.006247994,"domain_scores_codex":[0.9989339,0.0002091481,0.0001758686,0.0002992328,0.000154621,0.0002272721],"domain_scores_gemma":[0.9989824,0.00005142559,0.00002821819,0.0007500903,0.0000745117,0.0001133238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005618916,0.000053453,0.005774108,0.00001674901,0.00002676594,0.000002352278,0.00008480258,0.00002452329,0.984533,0.002388768,0.00009412142,0.006945197],"study_design_scores_gemma":[0.01295446,0.00132381,0.4269401,0.001198177,0.0001220047,0.001162915,0.0007071706,0.002006552,0.3124048,0.01584925,0.2222623,0.003068462],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752781,0.0125909,0.0008268975,0.009679352,0.00002539371,0.0003607417,0.0001759349,0.00001580011,0.001046932],"genre_scores_gemma":[0.9921142,0.002537657,0.004791947,0.000180866,0.00004547495,0.00005257515,0.00007361969,0.00001346519,0.0001901267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6721281,"threshold_uncertainty_score":0.4229926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550413823717359,"score_gpt":0.3003642868703625,"score_spread":0.2848601486331889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}