{"id":"W2404595262","doi":"10.1038/ncomms11704","title":"Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Directorate for Biological Sciences; National Institutes of Health; University of Aberdeen; Massachusetts Institute of Technology; Biotechnology and Biological Sciences Research Council; Fundo para o Desenvolvimento das Ciências e da Tecnologia; Universidade de Macau; Wellcome Trust; Burroughs Wellcome Fund","keywords":"HSF1; Candida albicans; Biology; Nucleosome; Heat shock protein; Promoter; Heat shock; Cell biology; Chromatin; Hsp90; Tiling array; Heat shock factor; Transcription factor; Chaperone (clinical); Virulence; Gene expression; Transcription (linguistics); Gene; Genetics; Transcriptome; Hsp70","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119991,0.0002629416,0.0002103088,0.0002097379,0.0002185182,0.0004667126,0.0002553551,0.0002671189,0.001035859],"category_scores_gemma":[0.000130446,0.0001709015,0.000243752,0.0001509443,0.0002050863,0.0002003391,0.0003719509,0.0003537081,0.0003334621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003958923,"about_ca_system_score_gemma":0.000337402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001779884,"about_ca_topic_score_gemma":0.003472473,"domain_scores_codex":[0.9998511,0.000007758215,0.000006130544,0.00004260196,0.00004323716,0.00004914129],"domain_scores_gemma":[0.9999247,0.000006792745,0.00001719915,0.00001043026,0.00001284506,0.00002804845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006676605,0.000008014132,0.0008443587,0.00001878561,0.000003893904,0.00002547221,0.00001592708,0.0002121248,0.9957579,0.0001350674,0.0001109271,0.00280084],"study_design_scores_gemma":[0.00001906233,0.0001229135,0.1240404,0.00001269607,0.00001838567,0.0002640679,0.0001053321,0.005369733,0.8656585,0.0003660771,0.003998084,0.00002470964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914747,0.001891674,0.003833218,0.0001133611,0.00002661477,0.00001628065,0.0006974069,0.000176401,0.001770367],"genre_scores_gemma":[0.9952968,0.0004136444,0.00151321,0.00006684769,0.000007784978,0.00001649655,0.0006101529,0.00002820289,0.002046964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779884,"threshold_uncertainty_score":0.003539085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550413823717359,"score_gpt":0.3003642868703625,"score_spread":0.2848601486331889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}