{"id":"W2404747198","doi":"10.1038/mt.2016.101","title":"Phase 1 Study of Intravenous Oncolytic Poxvirus (vvDD) in Patients With Advanced Solid Cancers","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Institutes of Health; National Cancer Institute; University of Pittsburgh","keywords":"Oncolytic virus; Medicine; Vaccinia; Pharmacokinetics; Adverse effect; Virus; Pharmacodynamics; Clinical endpoint; Refractory (planetary science); Immune checkpoint; Internal medicine; Immunology; Cancer; Oncology; Clinical trial; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839361,0.00022864,0.0002722525,0.0001206259,0.00003703772,0.000009279205,0.0003250279,0.00008730721,0.00004072466],"category_scores_gemma":[0.00001854416,0.0001590188,0.00005709844,0.0002195889,0.0001010982,0.00000629575,0.00004613468,0.00008643795,0.00000578882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000094737,"about_ca_system_score_gemma":0.000213071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005833344,"about_ca_topic_score_gemma":0.0002859754,"domain_scores_codex":[0.9983085,0.0001912795,0.0002787634,0.0004614253,0.0003685465,0.0003915016],"domain_scores_gemma":[0.9989786,0.00001162626,0.0001143117,0.000652047,0.000148416,0.00009500212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01833906,0.00289265,0.00380161,0.000004845737,0.0001610043,0.00001997019,0.0002221789,0.000217856,0.8358909,0.000001592482,0.000008965605,0.1384393],"study_design_scores_gemma":[0.03666092,0.07496412,0.00347898,0.00002779187,0.000008994987,8.338598e-7,0.0001056336,0.000005322811,0.8840752,0.00001924811,0.0003712045,0.0002817068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979765,0.0005095828,0.0002599823,0.00004258831,0.00004061285,0.00106293,0.0000210459,0.000009855653,0.0000768833],"genre_scores_gemma":[0.9993247,0.0001785496,0.00005630283,0.0001722417,0.00002329114,0.0001129475,0.00001848155,0.00005955572,0.00005393885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1381576,"threshold_uncertainty_score":0.6484599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060825327898403,"score_gpt":0.3094895745744175,"score_spread":0.2988813212954335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}