{"id":"W2404747198","doi":"10.1038/mt.2016.101","title":"Phase 1 Study of Intravenous Oncolytic Poxvirus (vvDD) in Patients With Advanced Solid Cancers","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Institutes of Health; National Cancer Institute; University of Pittsburgh","keywords":"Oncolytic virus; Medicine; Vaccinia; Pharmacokinetics; Adverse effect; Virus; Pharmacodynamics; Clinical endpoint; Refractory (planetary science); Immune checkpoint; Internal medicine; Immunology; Cancer; Oncology; Clinical trial; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000951048,0.001157005,0.001919498,0.0004266117,0.0005198234,0.00104388,0.0006922962,0.001192358,0.003143695],"category_scores_gemma":[0.0006877378,0.0005286212,0.001048093,0.0004116124,0.0009231081,0.0007944075,0.0003248497,0.00302834,0.0005934352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008859079,"about_ca_system_score_gemma":0.001705366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001370455,"about_ca_topic_score_gemma":0.00189005,"domain_scores_codex":[0.99962,0.0001469265,0.00001096295,0.00007097795,0.00002756901,0.0001236189],"domain_scores_gemma":[0.9996513,0.00008145169,0.00004625795,0.00004719559,0.00002407965,0.0001497383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5708076,0.169745,0.009958825,0.0007874274,0.00102374,0.0004022988,0.0006883339,0.008012485,0.08343795,0.001154506,0.005098437,0.1488834],"study_design_scores_gemma":[0.2267378,0.7491419,0.007779251,0.00002895512,0.0003245376,0.0002118102,0.0001284975,0.001905427,0.009118062,0.0003867748,0.004213837,0.00002316512],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939551,0.001018991,0.0007978712,0.0002844836,0.0001068924,0.001836735,0.0007089733,0.00005135805,0.001239592],"genre_scores_gemma":[0.9900256,0.001241918,0.001511276,0.0004347169,0.00009757478,0.002583136,0.001511326,0.00003478208,0.002559632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003143695,"threshold_uncertainty_score":0.0105167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060825327898403,"score_gpt":0.3094895745744175,"score_spread":0.2988813212954335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}