{"id":"W2404779005","doi":"10.1007/978-1-59745-170-3_29","title":"Isolation of Drug-Resistant Mutant HIV Variants Using Tissue Culture Drug Selection","year":2009,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Drug; Drug resistance; Selection (genetic algorithm); Mutant; Human immunodeficiency virus (HIV); Isolation (microbiology); Virus; Biology; Computational biology; Virology; Pharmacology; Bioinformatics; Genetics; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005069016,0.0004846425,0.0005907177,0.0006575449,0.000345188,0.00061217,0.000848078,0.0004728655,0.001969694],"category_scores_gemma":[0.0007517331,0.0003477974,0.0004765688,0.0004816704,0.0002667771,0.0001987055,0.0004909535,0.001084956,0.002572035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001827306,"about_ca_system_score_gemma":0.000193705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007234091,"about_ca_topic_score_gemma":0.0011483,"domain_scores_codex":[0.9994062,0.0001590938,0.00007961602,0.0001128447,0.0001746121,0.00006763073],"domain_scores_gemma":[0.9994242,0.0002091933,0.00005699469,0.0001476853,0.0001154891,0.00004651974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007095821,0.00006148492,0.0002950153,0.00004014981,0.000008809117,0.0001278455,0.00003483246,0.0001088759,0.9949067,0.0002449056,0.0001955748,0.003904874],"study_design_scores_gemma":[0.00003310054,0.0004790307,0.0022085,0.00002207075,0.00005923666,0.001053426,0.00003459537,0.002076269,0.9816134,0.0001284848,0.01227018,0.00002172758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7289237,0.008652708,0.2259854,0.0007257457,0.000741245,0.005342285,0.0068868,0.001006045,0.0217361],"genre_scores_gemma":[0.7464724,0.007835842,0.2054555,0.0005199676,0.0001317785,0.001686301,0.0119532,0.0004987255,0.0254464],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001969694,"threshold_uncertainty_score":0.006589293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01667301232826935,"score_gpt":0.3783515313429898,"score_spread":0.3616785190147205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}