{"id":"W2404993131","doi":"10.1097/hjh.0000000000000626","title":"Two candidate genes for two quantitative trait loci epistatically attenuate hypertension in a novel pathway","year":2015,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Epistasis; Quantitative trait locus; Genetics; Gene; Candidate gene; Function (biology); Biology; Computational biology; Mechanism (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578353,0.0007021169,0.0003331152,0.0004212186,0.0001893643,0.0001783985,0.0003399792,0.0003504508,0.003029067],"category_scores_gemma":[0.0002703118,0.0001396228,0.0004661422,0.0002011297,0.000260278,0.0001272296,0.0003321594,0.0004856777,0.000195591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003054479,"about_ca_system_score_gemma":0.0004277244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006033142,"about_ca_topic_score_gemma":0.000657361,"domain_scores_codex":[0.9998403,0.00002345916,0.00000841665,0.00006398756,0.00003133748,0.00003247485],"domain_scores_gemma":[0.9997929,0.00004506814,0.00007029243,0.00001336306,0.00002187399,0.00005652035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007504912,0.0001136831,0.008751323,0.00006161965,0.00005180059,0.001681475,0.00005252604,0.0001652768,0.9823869,0.0007339694,0.0001128534,0.005138121],"study_design_scores_gemma":[0.00123301,0.002397318,0.4634961,0.00004491235,0.0008352422,0.01950436,0.0002896582,0.0222873,0.4791138,0.0028647,0.007818229,0.0001154593],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834695,0.0003480485,0.01459907,0.0003123028,0.00002585063,0.00004881423,0.0003000735,0.000227452,0.0006689811],"genre_scores_gemma":[0.9893351,0.0001930764,0.007616977,0.0002073257,0.00002139154,0.00006639433,0.0004548825,0.00002758468,0.002077189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003029067,"threshold_uncertainty_score":0.01013327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07070952783038627,"score_gpt":0.312624886272411,"score_spread":0.2419153584420247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}