{"id":"W2405046015","doi":"10.1007/978-1-4939-0363-4_15","title":"Intranasal Delivery of Chitosan–siRNA Nanoparticle Formulation to the Brain","year":2014,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chitosan; Nasal administration; Nanoparticle; Chemistry; Nanotechnology; Pharmacology; Medicine; Materials science; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002453548,0.000164744,0.0003210801,0.0001428427,0.00007942774,0.000004305027,0.0003603827,0.000267749,0.00004849423],"category_scores_gemma":[0.000806127,0.0001301833,0.0000819318,0.0003815037,0.0001369667,0.00003716392,0.0001265944,0.000376036,0.00001621448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002285696,"about_ca_system_score_gemma":0.00002750636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003850578,"about_ca_topic_score_gemma":0.00002893178,"domain_scores_codex":[0.9940565,0.004676091,0.0004938323,0.0003116724,0.00007259385,0.0003893156],"domain_scores_gemma":[0.9979754,0.001409517,0.000145168,0.000335294,0.00003898203,0.00009564705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340728,0.00004925649,0.003389965,0.00001163661,0.00003640935,0.000002967452,0.0003988248,0.01019639,0.8890405,0.009885924,0.00006557007,0.08678852],"study_design_scores_gemma":[0.0007692068,0.0002183123,0.0007391402,0.000007985523,0.00002493848,0.000009037247,0.0000581897,0.01996643,0.9275555,0.00318175,0.04731271,0.000156779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4127878,0.0002377398,0.5833876,0.001916577,0.0006403716,0.0003581596,0.000007346595,0.00002324702,0.0006411645],"genre_scores_gemma":[0.8595724,0.00001343066,0.1362454,0.003978685,0.00009226121,0.00005463002,0.00000724864,0.00001733042,0.00001871159],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4471422,"threshold_uncertainty_score":0.5308721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07539567600664455,"score_gpt":0.4982651834658768,"score_spread":0.4228695074592322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}