{"id":"W2405138885","doi":"10.1158/1535-7163.targ-15-a150","title":"Abstract A150: Anti-BIRC6 antisense oligonucleotide inhibits enzalutamide-resistant castration-resistant prostate cancer growth in patient-derived xenograft model by suppressing multiple signaling pathways","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Occupational Cancer Research Centre; Spinal Cord Injury BC","funders":"","keywords":"Enzalutamide; Prostate cancer; Androgen receptor; Cancer research; Bicalutamide; Survivin; Apoptosis; Medicine; In vivo; Androgen; LNCaP; Cancer; Biology; Internal medicine; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373888,0.0004850187,0.0003419248,0.0003095929,0.0001564996,0.0001855917,0.0002287984,0.000313641,0.002051585],"category_scores_gemma":[0.00004516956,0.0001088309,0.0003070526,0.0001880951,0.0001596307,0.0001474423,0.0000761923,0.0009080946,0.000456481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002526632,"about_ca_system_score_gemma":0.0003451145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077703,"about_ca_topic_score_gemma":0.001416059,"domain_scores_codex":[0.9998825,0.00001233872,0.00001197933,0.00002733651,0.00003617157,0.0000297356],"domain_scores_gemma":[0.9999491,0.000006176127,0.00001036566,0.000005415523,0.000008285659,0.00002061326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003070145,0.0002651099,0.00009373251,0.00006424655,0.000009065346,0.00003611611,0.00001198439,0.00008413313,0.9971868,0.00009946431,0.0002721931,0.001570069],"study_design_scores_gemma":[0.0001387272,0.004229102,0.002178023,0.000007076792,0.00003863412,0.0002726627,0.00002101431,0.001139021,0.9882389,0.00002989899,0.003700051,0.000006781169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886792,0.002381217,0.003116707,0.0002016238,0.0002359141,0.0001647163,0.001457288,0.0003315599,0.003431701],"genre_scores_gemma":[0.9830876,0.001557006,0.004777614,0.0001371662,0.00003623861,0.0001873494,0.002733304,0.00003058298,0.007453106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002051585,"threshold_uncertainty_score":0.006863236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0526247472187007,"score_gpt":0.3056723633710119,"score_spread":0.2530476161523112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}