{"id":"W2405171365","doi":"10.1016/s2213-8587(16)30041-9","title":"Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel","year":2016,"lang":"en","type":"review","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":418,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Hospital; Western University","funders":"British Heart Foundation","keywords":"Medicine; Familial hypercholesterolemia; Subclinical infection; Disease; Internal medicine; Cholesterol; Myocardial infarction; Risk stratification; Ldl cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01412194,0.001272487,0.004816146,0.00264901,0.0006164387,0.002281285,0.00293748,0.004275138,0.001532924],"category_scores_gemma":[0.01137038,0.0006540377,0.002490715,0.002692356,0.0009039187,0.002206031,0.00199132,0.006824983,0.0009121964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00244893,"about_ca_system_score_gemma":0.008929359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008205501,"about_ca_topic_score_gemma":0.01906578,"domain_scores_codex":[0.9969679,0.0006671119,0.001035269,0.0002981788,0.0008546889,0.0001769126],"domain_scores_gemma":[0.9916782,0.003396941,0.001173658,0.000143046,0.003040032,0.0005680519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003958288,0.0001030781,0.002571206,0.03425819,0.001248704,0.0002894601,0.0002861268,0.0004722042,0.0009394118,0.004784112,0.1788767,0.7757751],"study_design_scores_gemma":[0.0005086843,0.0001724597,0.01128696,0.1075315,0.003383763,0.001417893,0.0005513282,0.000425015,0.0005677328,0.007190223,0.8668033,0.0001610392],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002976937,0.9751081,0.0005392167,0.02057789,0.002529901,0.00004383991,0.000186927,0.00001007843,0.0007064585],"genre_scores_gemma":[0.002755429,0.9812272,0.002674175,0.01020714,0.002033659,0.00009523465,0.0005205577,0.000009293601,0.0004774303],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01412194,"threshold_uncertainty_score":0.0746848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1212313925336928,"score_gpt":0.3749064451119221,"score_spread":0.2536750525782293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}