{"id":"W2405755467","doi":"10.1128/jvi.00186-16","title":"Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Biology; Serine protease; Interferon regulatory factors; Herpes simplex virus; Virology; Interferon; NS3; Protease; IRF3; Virus; Enzyme; Innate immune system; Immunology; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004863033,0.0001876763,0.0004086241,0.0001419878,0.0001179665,0.000009217955,0.0002663605,0.0002587932,0.0009762183],"category_scores_gemma":[0.0003069714,0.000101278,0.0001691188,0.00006202939,0.0004110632,0.0001757963,0.00008990779,0.0003389213,0.00002361153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007183068,"about_ca_system_score_gemma":0.000110134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002749116,"about_ca_topic_score_gemma":0.00000839346,"domain_scores_codex":[0.998073,0.0006795592,0.0007345448,0.0001486431,0.00006607903,0.0002982171],"domain_scores_gemma":[0.9980844,0.0005586557,0.0009067144,0.0002114896,0.0002123209,0.00002646857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00336334,0.00009955213,0.0001006225,0.00001099105,0.0001824686,0.000004617867,0.0003337667,0.0000021857,0.9263917,0.00003200835,0.001468958,0.06800986],"study_design_scores_gemma":[0.001722279,0.001765176,0.001574548,0.0001329259,0.00002647672,0.000277766,0.0001874044,0.000003589492,0.9645362,0.00008675377,0.02957957,0.0001073046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962699,0.0005846643,0.001294272,0.001216475,0.0003768328,0.000152821,0.00003038867,0.00001314671,0.00006144977],"genre_scores_gemma":[0.9989213,0.00003035962,0.00002896656,0.0001966978,0.00007653495,0.000001944951,0.00000318122,0.00001872977,0.000722227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06790255,"threshold_uncertainty_score":0.999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251665176400851,"score_gpt":0.2384359725944638,"score_spread":0.2259193208304552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}