{"id":"W2406081450","doi":"10.1074/jbc.m116.715805","title":"Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Protein kinase B; microRNA; Muscle hypertrophy; Cell biology; FOXO1; Signal transduction; Biology; Fibrosis; Transgene; Cancer research; Internal medicine; Endocrinology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439084,0.0003353813,0.0003489146,0.0002336243,0.0001861224,0.000505248,0.000168771,0.0002753545,0.001077767],"category_scores_gemma":[0.0001592112,0.0002014654,0.0003973832,0.0001107013,0.0002254183,0.0002328761,0.0002560696,0.0007910188,0.0006701589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001990891,"about_ca_system_score_gemma":0.0002847804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001951919,"about_ca_topic_score_gemma":0.0004144072,"domain_scores_codex":[0.9998307,0.00001831646,0.00002283656,0.00003382988,0.00006253857,0.00003170259],"domain_scores_gemma":[0.9998925,0.00001542169,0.00002900836,0.00001364196,0.00002031311,0.00002919837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005642762,0.00001538124,0.0002098321,0.00003779044,0.000005377882,0.00004372928,0.00001209749,0.00003739119,0.9977871,0.0001388558,0.00005700615,0.001599112],"study_design_scores_gemma":[0.00001263638,0.000147359,0.004635472,0.00000901751,0.00004067215,0.0003230322,0.00003047171,0.000882811,0.9875586,0.0001176676,0.006234235,0.000008176351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730315,0.003932081,0.01436241,0.0003959758,0.0002428938,0.00006549765,0.0005231255,0.0007171133,0.006729272],"genre_scores_gemma":[0.9870703,0.00199374,0.007044444,0.0002171473,0.00003974641,0.00003754765,0.0004624458,0.0001184816,0.003016147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077767,"threshold_uncertainty_score":0.003605485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899285322817843,"score_gpt":0.2414143996440945,"score_spread":0.2224215464159161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}