{"id":"W2406239697","doi":"10.4137/bic.s31798","title":"The Role of Biomarkers in Decreasing Risk of Cardiac Toxicity after Cancer Therapy","year":2016,"lang":"en","type":"review","venue":"Biomarkers in Cancer","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canada Research Chairs","keywords":"Medicine; Cardiotoxicity; Toxicity; Internal medicine; Troponin; Cardiology; Trastuzumab; Heart failure; Ejection fraction; Cardiomyopathy; Anthracycline; Cancer; Pharmacology; Myocardial infarction; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001183352,0.000438996,0.001792215,0.000373773,0.0000452393,0.00001257811,0.0002422862,0.0005435428,0.0001602806],"category_scores_gemma":[0.000118096,0.000275749,0.0009374109,0.0008069924,0.000364959,0.00006997441,0.00004877756,0.0003238399,0.000001557874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009588533,"about_ca_system_score_gemma":0.001173118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003262015,"about_ca_topic_score_gemma":0.0007965621,"domain_scores_codex":[0.9970889,0.0005370187,0.001004227,0.0004966784,0.0004482612,0.0004249358],"domain_scores_gemma":[0.9978172,0.0005572553,0.0007680925,0.0006400976,0.0001144294,0.0001029509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007844714,0.00006353836,0.009665151,0.001827004,0.002743577,0.000003002973,0.0001449542,1.494201e-7,0.002749736,0.000004420578,0.0001347813,0.9818792],"study_design_scores_gemma":[0.001490314,0.00008187943,0.007029877,0.04109048,0.0006798555,0.00000539605,0.0001314851,0.00000454914,0.03317901,0.00009163799,0.9157741,0.0004414068],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03184718,0.9645686,0.000002167104,0.00006616279,0.0004807041,0.001502582,0.0004189831,0.00001380898,0.001099824],"genre_scores_gemma":[0.01394339,0.9844827,0.00006774677,0.00003454064,0.0002261536,0.001116664,0.00001346897,0.00007496148,0.00004035866],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9814378,"threshold_uncertainty_score":0.9999695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384629155390386,"score_gpt":0.3359954279188797,"score_spread":0.3121491363649759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}