{"id":"W2406260795","doi":"10.1021/acs.analchem.5b03295","title":"Process Analytical Utility of Raman Microspectroscopy in the Directed Differentiation of Human Pancreatic Insulin-Positive Cells","year":2015,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Spectroscopy Techniques in Biomedical and Chemical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Chemistry; Enteroendocrine cell; Induced pluripotent stem cell; Nucleic acid; Cell; Insulin; Directed differentiation; Stem cell; Embryonic stem cell; Cell culture; Cellular differentiation; Cell biology; Endocrine system; Endocrinology; Biochemistry; Biology; Hormone; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008177602,0.0004345984,0.0001552191,0.000490171,0.0002506877,0.0004057374,0.0002626742,0.000282709,0.0004058586],"category_scores_gemma":[0.000662477,0.000175633,0.0002556854,0.0003261188,0.0003840121,0.0002650144,0.0003587537,0.000457399,0.0002112636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074629,"about_ca_system_score_gemma":0.0003263007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004919277,"about_ca_topic_score_gemma":0.0008832559,"domain_scores_codex":[0.999653,0.00009529779,0.00002170167,0.00007830457,0.0001243716,0.00002736558],"domain_scores_gemma":[0.9995916,0.0002284046,0.00004637666,0.0000467634,0.00006819951,0.00001862278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002221562,0.00001192007,0.0002521032,0.00001622347,0.000002576252,0.00003372971,0.00003734696,0.0001641124,0.9962165,0.0001289511,0.000009088459,0.003105238],"study_design_scores_gemma":[0.000002688718,0.00007672747,0.00122854,0.000002246919,0.000008036412,0.000087115,0.00002656138,0.002006998,0.9960734,0.00009534701,0.0003866881,0.000005535062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7193641,0.001676082,0.2742417,0.0001706116,0.00003867259,0.0001883534,0.0002604236,0.0003792425,0.003680796],"genre_scores_gemma":[0.7612699,0.001651396,0.2351841,0.0000828097,0.00001438793,0.000114937,0.0001841395,0.00005888777,0.00143936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008177602,"threshold_uncertainty_score":0.004324794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01739304062256785,"score_gpt":0.3439995100728676,"score_spread":0.3266064694502998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}