{"id":"W2406400975","doi":"10.1074/jbc.m115.663666","title":"FANCD2-associated Nuclease 1, but Not Exonuclease 1 or Flap Endonuclease 1, Is Able to Unhook DNA Interstrand Cross-links in Vitro","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Nuclease; Exonuclease; Endonuclease; DNA; In vitro; Molecular biology; Biology; Chemistry; Genetics; DNA polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008297308,0.000356054,0.0005488457,0.00006037043,0.00005711496,0.00008668303,0.000634525,0.0009114272,0.0003113609],"category_scores_gemma":[0.002122905,0.0002682747,0.0003272207,0.0001906779,0.0001467928,0.0000188979,0.0002878665,0.0006789686,0.00003826725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835792,"about_ca_system_score_gemma":0.0002893572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001342916,"about_ca_topic_score_gemma":0.000003214807,"domain_scores_codex":[0.9976195,0.0001046675,0.0008484168,0.0005070594,0.0003523074,0.0005680353],"domain_scores_gemma":[0.9978955,0.00004723321,0.0004251881,0.0003897185,0.0003767174,0.00086569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006706753,0.0004016556,0.0005493241,0.00002363717,0.00008034811,0.0004168348,0.00007038969,0.00003634818,0.9870034,9.399958e-7,0.004103495,0.0006068341],"study_design_scores_gemma":[0.003183979,0.0009053798,0.0003849308,0.00006195442,0.00002654017,0.0002024724,0.0002955644,0.00005471676,0.9860407,0.00007714566,0.008404127,0.0003624983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979197,0.0001579614,0.0001142962,0.0004904413,0.000198764,0.0001630323,0.0001290035,0.00002407773,0.0008026865],"genre_scores_gemma":[0.9949844,0.00005583739,0.001117557,0.002163419,0.0003756063,0.000008271148,0.00004264354,0.00003795386,0.001214255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004300633,"threshold_uncertainty_score":0.9999769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03397934662058682,"score_gpt":0.283077490947768,"score_spread":0.2490981443271811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}