{"id":"W2406500772","doi":"10.1158/1538-7445.am2019-568","title":"Abstract 568: Decoding shared antigenic epitopes and their cognate TCR genes in melanoma TILs using a library of paired human cell-based pHLA multimers and artificial APCs","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Wellcome Trust","keywords":"Antigen; Epitope; Human leukocyte antigen; Melanoma; T-cell receptor; Immunology; T cell; Biology; Adoptive cell transfer; Cancer research; Immunotherapy; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211153,0.00022254,0.000187354,0.0001561088,0.00008702178,0.0002349565,0.0001022208,0.0001850607,0.001395745],"category_scores_gemma":[0.000155472,0.0001059419,0.0001589627,0.0001374875,0.0000801992,0.0001240777,0.0001880716,0.0003536629,0.0004824931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001318963,"about_ca_system_score_gemma":0.0001178684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001431336,"about_ca_topic_score_gemma":0.0001708193,"domain_scores_codex":[0.9999013,0.00002030198,0.000008672288,0.00002430397,0.00002493127,0.00002043719],"domain_scores_gemma":[0.9999522,0.00001328925,0.000007486548,0.000009026842,0.000006613816,0.00001147661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009144207,0.00002666995,0.000345164,0.00001079954,0.000002892585,0.00002920333,0.000007940494,0.0002598172,0.9971725,0.00002457469,0.00002130359,0.002007751],"study_design_scores_gemma":[0.00002013423,0.0004485225,0.002089639,0.000003484812,0.00001825993,0.0002659594,0.00001585872,0.003921391,0.9916544,0.00003295833,0.001527091,0.000002401535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931629,0.0002573909,0.005525279,0.00003210691,0.00001336104,0.00003582529,0.000178995,0.00005439675,0.0007398896],"genre_scores_gemma":[0.9930617,0.0001638219,0.004851277,0.00003715283,0.000007173319,0.0000341589,0.0005147135,0.00001797231,0.001311881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395745,"threshold_uncertainty_score":0.004669189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1312969369451226,"score_gpt":0.4001343901412052,"score_spread":0.2688374531960825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}